Effects of scheduled food and water deprivation on food intake, water intake and body weight of cage-adapted and cage-naive rats |
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| Authors: | K Gillette-Bellingham W P Bellingham L H Storlien |
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| Affiliation: | 1. Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA;2. Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA;3. Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA;1. Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China;2. Department of Breast and Thyroid Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China;1. Center for Neuroscience, University of Pittsburgh, 453 Fifth and Ruskin Avenue, Langley Hall, Suite A210, Pittsburgh, PA 15260, USA;2. Department of Physical Medicine & Rehabilitation, University of Pittsburgh, School of Medicine, 3471 Fifth Avenue, Kaufmann Building, Suite 202, Pittsburgh, PA 15213, USA;3. Safar Center for Resuscitation Research, University of Pittsburgh, 3434 Fifth Avenue Hill Building, Pittsburgh, PA 15213, USA;4. Department of Neurological Sciences, Carnegie Mellon University, Mellon College of Science, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA;5. Department of Neurobiology, University of Pittsburgh, School of Medicine, 3501 Fifth Avenue, Biomedical Science Tower 3, Room 6061, Pittsburgh, PA 15261, USA |
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| Abstract: | The first experiment examined the effects of four food-deprivation schedules and four water-deprivation schedules on body weight, food intake and water intake of adult rats over ten days of deprivation and two days of recovery. During food deprivation, water intake was gradually reduced. During water deprivation, daily food intake was initially depressed but eventually returned to ad libitum levels. Consumption of restricted commodities increased over the deprivation phase. Experiment 2 showed that mutual deprivation of food and water are more apparent in rats not previously adapted to the test environment and the final experiment indicated that this was due to the inexperience of cage-naive rats in feeding under novel conditions. The results are evaluated in relation to the environmental factors that may play as great a role as physiological processes in regulating the feeding/drinking behaviour of laboratory rats. |
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