中重度睡眠呼吸暂停综合征患者冠状动脉造影特点分析

目的观察合并中重度阻塞性睡眠呼吸暂停综合征(OSAS)合并冠心病(CHD)患者冠状动脉(简称冠脉)造影特点。方法应用冠脉造影观察中重度OSAS合并CHD患者(n=92)以及非OSAS合并CHD患者(n=100)冠状动脉病变特点,并应用酶联免疫方法测定两组患者血浆内皮素-1(ET-1)及C反应蛋白(CRP)浓度。结果中重度OSAS合并CHD患者在冠状动脉血管病变支数、闭塞性病变总数、血管钙化、血管严重迂曲、存在桥侧支所占比例均明显高于非OSAS组(P<0.05),闭塞段血管长度也显著高于非OSAS组,两组的TIMI血流情况差异亦有统计学意义(P<0.01);中重度OSAHS合并CHD患者血浆ET-1、CRP均较对照组显著增高(121.57±31.8 vs 68.23±23.12,P=0.0032;12.75±3.48 vs 5.74±2.19,P=0.029)。结论中重度OSAS合并CHD患者较非OSAS合并CHD患者有更重的冠状动脉病变,这可能与内皮功能损伤及炎性反应异常有关。

Clinnical angiographic manifestation of coronary heart disease with middle-severe obstructive sleeping apnea syndrome

Objective To analyse the pathogenic angiographic manifestation of coronary heart disease with obstructive sleeping apnea syndrome.Methods The clinical and coronary angiographic data,endothelia-1(ET-1) and C reactive protein CRP were compared among the patients with coronary heart disease(CHD) with(n=92) or without(n=100) obstructive sleeping apnea syndrome(OSAS).Apnea hypopnea index(AHI) of 20 was used as cutoff value.Results OSAS group had more coronary lesions compared to the CHD patients without OSAS(P<0...