Hyperpolarized helium‐3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation |
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| Authors: | Miranda Kirby BSc Nikhil Kanhere BE Roya Etemad‐Rezai MD David G. McCormack MD Grace Parraga PhD |
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| Affiliation: | 1. Imaging Research Laboratories, Robarts Research Institute, London, Canada;2. Department of Medical Biophysics, University of Western Ontario, London, Canada;3. Graduate Program in Biomedical Engineering, University of Western Ontario, London, Canada;4. Department of Medical Imaging, University of Western Ontario, London, Canada;5. Division of Respirology, Department of Medicine, University of Western Ontario, London, Canada |
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| Abstract: | A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium‐3 (3He) magnetic resonance imaging (MRI) serially over 4 years, twice prior to and twice following an acute exacerbation (AE). About 2.5 years pre‐AE, 3He ventilation defect percent (VDP) was 16%, the apparent diffusion coefficient (ADC) was 0.34 cm2/s, and forced expiratory volume in 1 sec (FEV1) was 41%pred. Six months pre‐AE, VDP and ADC were worse (29% and 0.38 cm2/s, respectively) without worsening FEV1 (47%pred). After hospitalization and AE treatment, VDP was 20%, whereas FEV1 did not improve (45%pred); 16 months post‐AE, both VDP and ADC remained improved and similar to 4 years prior. J. Magn. Reson. Imaging 2013;37:1223–1227. © 2012 Wiley Periodicals, Inc. |
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| Keywords: | hyperpolarized 3He MRI chronic obstructive pulmonary disease exacerbation |
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