β‐amyloid in lewy body disease is related to Alzheimer's disease‐like atrophy |
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| Authors: | Hitoshi Shimada MD PhD Hitoshi Shinotoh MD PhD Shigeki Hirano MD PhD Michie Miyoshi MD PhD Koichi Sato MD PhD Noriko Tanaka MD PhD Tsuneyoshi Ota MD PhD Kiyoshi Fukushi PhD Toshiaki Irie PhD Hiroshi Ito MD PhD Makoto Higuchi MD PhD Satoshi Kuwabara MD PhD Tetsuya Suhara MD PhD |
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| Affiliation: | 1. Molecular Imaging Center, Molecular Neuroimaging Program, National Institute of Radiological Sciences, , Chiba, Japan;2. Section for Human Neurophysiology, Research Center for Frontier Medical Engineering, Chiba University, , Chiba, Japan;3. Neurology Chiba, , Chiba, Japan;4. Department of Neurology, Graduate School of Medicine, Chiba University, , Chiba, Japan;5. Department of Psychiatry, Teikyo University Chiba Medical Center, , Chiba, Japan;6. Department of Psychiatry, Juntendo University School of Medicine, , Tokyo, Japan;7. Molecular Imaging Center, Molecular Probe Program, National Institute of Radiological Sciences, , Chiba, Japan;8. Molecular Imaging Center, Biophysics Program, National Institute of Radiological Sciences, , Chiba, Japan |
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| Abstract: | The aim of this study was to investigate whether amyloid deposition is associated with Alzheimer's disease (AD)‐like cortical atrophy in Lewy body (LB) disease (LBD). Participants included 15 LBD with dementia patients (8 with dementia with Lewy bodies [DLB] and 7 with Parkinson's disease [PD] with dementia [PDD]), 13 AD patients, and 17 healthy controls. Age, gender, and Mini–Mental State Examination scores were matched between patient groups. All subjects underwent PET scans with [11C]Pittsburgh Compound B to measure brain amyloid deposition as well as three‐dimensional T1‐weighted MRI. Gray‐matter volumes (GMVs) were estimated by voxel‐based morphometry. Volumes‐of‐interest analyses were also performed. Forty percent of the 15 DLB/PDD patients were amyloid positive, whereas all AD patients and none of the healthy controls were amyloid positive. Amyloid‐positive DLB/PDD and AD patients showed very similar patterns of cortical atrophy in the parahippocampal area and lateral temporal and parietal cortices, with 95.2% of cortical atrophy distribution being overlapped. In contrast, amyloid‐negative DLB/PDD patients had no significant cortical atrophy. Compared to healthy controls, parahippocampal GMVs were reduced by 26% in both the amyloid‐positive DLB/PDD and AD groups and by 10% in the amyloid‐negative DLB/PDD group. The results suggest that amyloid deposition is associated with AD‐like atrophy in DLB/PDD patients. Early intervention against amyloid may prevent or delay AD‐like atrophy in DLB/PDD patients with amyloid deposition. © 2012 Movement Disorder Society |
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| Keywords: | voxel‐based morphometry dementia with Lewy bodies Parkinson's disease with dementia Alzheimer's disease amyloid PET |
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