Preclinical evaluation of holmium‐166 labeled anti‐VEGF‐A(Bevacizumab) |
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| Authors: | Alireza Khorami‐Moghadam Bahram Bolouri Amir Reza Jalilian Nariman Mosafa Ali Bahrami‐Samani Seyed Mohammad Mazidi Behrouz Alirezapour |
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| Affiliation: | 1. Medical Physics Department, Tehran University of Medical Sciences (TUMS), , Tehran, Iran;2. Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), , Tehran, 14155‐1339 Iran |
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| Abstract: | Radiolabeled antiangiogenic monoclonal antibodies are potential agents for targeted therapy in specific types of malignancies. In this study, 166Ho‐DOTA‐Bevacizumab was used in biodistribution studies using single‐photon emission computed tomography (SPECT) to acquire dosimetric aspects of the radiolabeled antibody in mice. The liver toxicity of the radiolabeled antibody was also determined using serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase and alkaline phosphatase assay 2–7 days post‐injection. The SPECT biodistribution demonstrated a similar pattern as the other radiolabeled anti‐ vascular endothelial growth factor A (VEGF‐A) immunoconjugates.166Ho‐DOTA‐Bevacizumab was revealed as a potential compound for therapy/imaging of VEGF‐A expression in oncology. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | holmium‐166 bevacizumab radiolabeling conjugation biodistribution |
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