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Motor unit firing pattern of vastus lateralis muscle in type 2 diabetes mellitus patients |
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| Authors: | Kohei Watanabe PhD Marco Gazzoni PhD Ales Holobar PhD Toshiaki Miyamoto PhD Kazuhito Fukuda MD Roberto Merletti PhD Toshio Moritani PhD |
| Affiliation: | 1. School of International Liberal Studies, Chukyo University, , Showa‐ku, Nagoya, 466–8666 Japan;2. Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, , Kyoto, Japan;3. Laboratory of Engineering of the Neuromuscular System, Politecnico di Torino, , Torino, Italy;4. Faculty of Electrical Engineering and Computer Science, University of Maribor, , Maribor, Slovenia;5. First Department of Internal Medicine, University of Toyama, , Toyama, Japan |
| Abstract: | Introduction: We investigated the motor unit (MU) firing pattern in type 2 diabetes mellitus (T2DM) patients by means of multichannel surface electromyography (SEMG). Methods: Eight T2DM patients and 8 age‐matched, healthy men performed a ramp‐up contraction to 20% of maximal voluntary contraction (MVC). They also performed a sustained contraction at 10% of MVC during isometric knee extension. Multichannel SEMG signals recorded from the vastus lateralis muscle were decomposed with the convolution kernel compensation technique to extract individual MU firing patterns. Results: During the ramp contraction, the extent of MU firing modulation was significantly attenuated in T2DM. Variability of MU firing rate was significantly higher in T2DM at later periods during the sustained contraction. Conclusions: Our findings suggest that T2DM patients manifest characteristic MU activity patterns due possibly to some degree of neuromuscular impairment affecting the integrity of MU firing modulation. Muscle Nerve 48:806–813, 2013 |
| Keywords: | firing rate knee extensors multichannel surface electromyography type 2 diabetes mellitus vastus lateralis |