| 红曲降低肾血管型高血压大鼠血压的生化机制 |
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| 引用本文： | 雷萍,郭俊霞,金宗濂.红曲降低肾血管型高血压大鼠血压的生化机制[J].辽宁中医药大学学报,2007,9(3):217-218. |
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| 作者姓名： | 雷萍 郭俊霞 金宗濂 |
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| 作者单位： | 1. 辽宁中医药大学,辽宁,沈阳,110032
2. 北京市生物活性物质与功能食品重点实验室,北京,100083 |
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| 摘 要： | 目的:初探红曲降低肾血管型高血压大鼠(Renovascular Hypertensive Rats,RHR)血压的生化机制.方法:通过试剂盒测定灌胃红曲4周后RHR肺组织ACE活性和主动脉NOS活性,以及灌胃红曲前后血浆ET和CGRP的变化.结果:灌胃4周后.红曲高剂量组和低剂量组肺ACE与阴性对照组相比显著下降(P＜0.01);红曲高和低剂量组血浆ET均比阴性对照组低20个单位(P＜0.01);红曲高剂量组血浆CGRP比灌胃前增高9个单位(P＜0.01),比阴性时照组高7个单位(P＜0.05).结论:红曲的降压途径可能是多方面的:在RHR上可能主要通过抑制肺ACE起到降压作用,同时也能降低血浆ET和升高血浆CGKP.
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| 关 键 词： | 红曲 降压 |
| 文章编号： | 1673-842X（2007）03-0217-02 |
| 修稿时间： | 2006-12-18 |
Biochemistry Mechanism of Red Yeast Rice on Renovascular Hypertensive Rats |
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| LEI Ping,GUO Jun-xia,JIN Zong-lian.Biochemistry Mechanism of Red Yeast Rice on Renovascular Hypertensive Rats[J].Journal of Liaoning University of Traditional Chinese Medicine,2007,9(3):217-218. |
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| Authors: | LEI Ping GUO Jun-xia JIN Zong-lian |
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| Institution: | 1 .Liaoning University of TCM, Shenyang 110032, Liaoning, China ; 2.Beijing Key Laboratory of Biological Activated Substance and Function Food, Beijing 100083, China |
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| Abstract: | Objective:To study the biochemistry mechanism of red yeast rice on RHR.Methods: The lung ACE,aorta NOS,plasma ET and plasma CGRP of RHR were inspected by using kits.Results: It showed that the lung ACE of the two red yeast rice groups decreased significantly compared with control group after 4 weeks(P<0.01)t;he plasma ET of two red yeast rice groups decreased significantly compared with control group(P<0.01),the plasma CGRP of high dose group increased significantly compared with 4 weeks ago(P<0.01),and increased significantly compared with control group(P<0.05).Conclusion: There might be many ways of the hypotensive mechanism of red yeast ricei:t mainly inhibited lung ACE,also decreased plasma ET and increased plasma CGRP on RHR. |
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| Keywords: | RHR ACE NOS ET CGRP |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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