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| 黏质沙雷氏菌苗治疗恶性胸腔积液的临床研究 | |
| 引用本文： | Shi H,Zhu Y,Xu L,Liu Z,You Y,Meng Q,Zhang X,Xu J. 黏质沙雷氏菌苗治疗恶性胸腔积液的临床研究[J]. 中华肿瘤杂志, 2002, 24(2): 188-190 |
| 作者姓名： | Shi H Zhu Y Xu L Liu Z You Y Meng Q Zhang X Xu J |
| 作者单位： | 101149,北京胸部肿瘤结核病医院 |
| 摘 要： | 目的 评价黏质沙雷氏菌苗（S311）治疗恶性胸腔积液的疗效及毒副反应。方法 取S311 10^9U(0.32mg)于第1,8,15天注入胸腔。观察4周,评价疗效和毒副反应。结果 34例患者中,完全缓解（CR）12例,部分缓解（PR）21例,总有效率97.1%(33/34)。毒副反应较轻,有发热（82．4％）、胸痛（52．9％）、恶心（26．5％）、呼吸困难（17．5％）、寒战（5．9％）及呕吐（2．9％）。结论 S311治疗恶性胸腔积液疗效较好,毒副反应可以耐受,可以安全用于临床。 |
| 关 键 词： | 恶性胸腔积液 黏质沙雷氏菌苗 治疗 临床研究 疗效 |
| 修稿时间： | 2001-08-09 |
Serratia marcescens vaccine in the treatment of malignant pleural effusion |
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| Shi Heling,Zhu Yunzhong,Xu Liyan,Liu Zhe,You Yonghong,Meng Qiyi,Zhang Xinyong,Xu Juntao. Serratia marcescens vaccine in the treatment of malignant pleural effusion[J]. Chinese Journal of Oncology, 2002, 24(2): 188-190 | |
| Authors: | Shi Heling Zhu Yunzhong Xu Liyan Liu Zhe You Yonghong Meng Qiyi Zhang Xinyong Xu Juntao |
| Affiliation: | Beijing Thoracic Tumour and Tuberculosis Hospital, Beijing 101149, China. |
| Abstract: | Objective To evaluate the efficacy and toxicity of Serratia marce scens (S311) vaccine in the treatment of malignant pleural effusion. Methods Thirty four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10 9U (0.32mg) on D 1, 8 and 15, and o bserved for four weeKs. Results The overall response rate (CR PR) was 97.1% (CR in 12 patien ts and PR in 21 patients). The sy stemic toxicity was mild, including fever (82.4 %), pleuritic pain (50.7%), nansea (26.5%), dy spnea (17.5%) and chills (5.9 %). Conclusion Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warr anted. [ |
| Keywords: | Pleural effusion/therapy Serratia marcecens |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |