胰腺混合性腺泡- 神经内分泌癌1例报道及文献复习

目的:探讨胰腺混合性腺泡-神经内分泌癌(MANEC)的临床病理特征、鉴别诊断和治疗方法。方法:回顾性分析收治的1例胰腺MANEC患者的临床资料,结合国内外文献,总结该病的临床特点、病理特征、鉴别诊断和治疗方法。结果:该患者术前影像学检查提示十二指肠降部肿瘤,行手术治疗,术后病理提示胰腺MANEC。术后患者顺利出院,20个月后复查CT提示肿瘤无复发转移。结论:胰腺MANEC是非常罕见的肿瘤,常无典型的症状,最终需要病理确诊。预后至今不清楚,但是早期的手术治疗能显著提高总的生存期。

Mixed acinar-neuroendocrine carcinoma of the pancreas: a case report and literature review

Objective: To investigate the clinicopathologic features, and differential diagnosis and treatment method of themixed acinar-neuroendocrine carcinoma (MANEC) of the pancreas.Methods: The clinical record of one patient with MANEC was retrospectively analyzed, in combination withdomestic and foreign literature review, to summarize the clinical features, pathological features, differentialdiagnosis and treatment method for this disease.Results: Preoperative imaging examinations suggested that the patient had a tumor of descendingduodenum, and then the patient underwent surgical treatment. The pathological diagnosis was pancreaticMANEC. The patient was discharged after operation and no tumor recurrence or metastasis was noted 20months later.Conclusion: MANEC of the pancreas is extremely rare, usually without typical symptoms, and the finaldiagnosis depends on pathological findings. Its prognosis remains unclear to date, but early surgical treatment cansignificantly improve the overall survival.