丹参注射液合用黄芪注射液治疗冠心病心绞痛的Meta分析

目的:系统评价丹参注射液合用黄芪注射液治疗冠心病心绞痛的疗效及安全性.方法:计算机检索PudMed、Co-chrane、中国学术期刊数据库(CSPD)、国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)和中文科技期刊数据库(CCD)数据库,检索时间为建库至2020年3月,收集关于丹参注射液联合黄芪注射...

Meta analysis of Danshen Injection and Huangqin Injection in the Treatment of Coronary Heart Disease with Angina Pectoris

To systematically evaluate the efficacy and safety of Danshen Injection and Huangshen Injection in the treatment of coronary heart disease with angina pectoris.Methods:Computer searched PudMed,Cochrane,CNKI,Wanfang,VIP and CBM database from the establishment of the library to March 2020 to collect randomized controlled trial of Danshen Injection combined with Huangqin Injection in the treatment of coronary heart disease and angina pectoris.A total of 2 reviewers extracted data according to the inclusion and exclusion criteria of the disease.The quality was evaluated according to the Jadad scale,and the RevMan 5.3 software was used for systematic evaluation.Results:A total of 2880 patients in 29 RCTs were included in the study.Meta-analysis showed that in terms of total effective rate and ECG improvement,the combined use of two injections was better than Danshen Injection alone in the treatment of coronary heart disease angina pectoris,and the difference was statistically significant(OR=4.77,95%CI [3.79 to 6.00],P<0.000 01; OR=3.96,95%CI [3.14 to 5.00],P<0.000 01); in terms of the improvement of angina pectoris,the frequency and duration of angina pectoris in the experimental group was superior to that of the control group; In terms of hemorheology,some indicators were statistically different; In terms of adverse reactions,the difference was not statistically significant(OR=1.22,95%CI [0.34 to 4.35],P=0.76).Conclusion:In the treatment of coronary heart disease angina pectoris,in the same case of conventional Western medicine treatment,the clinical efficacy,electrocardiogram improvement,angina pectoris improvement and hemorheology improvement of Danshen combined with Huangqi Injection compared with Danshen injection alone were more significant.