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Power spectral analysis of the electroencephalographic and hemodynamic correlates of propofol anesthesia in the rat: Intravenous infusion |
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| Authors: | Peter P. C. Tan Ming-Hwang Shyr Chen-Hsein Yang Terry B. J. Kuo Wynn H. T. Pan Samuel H. H. Chan |
| Affiliation: | a Department of Anaesthesia, Chang-Gung Memorial Hospital-Taipei, Taipei, Taiwan, Republic of China b Graduate Institute of Clinical Medicine, Chang-Gung Medical College, Taipei, Taiwan, Republic of China c Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China |
| Abstract: | Based on the tail-flick response to noxious thermal stimuli, we determined in the present study that effective antinociception could be achieved in adult male Sprague-Dawley rats 15 min after intravenous infusion of propofol at 60 mg/kg/h. Simultaneous power spectral analysis of the electroencephalographic (EEG) and systemic arterial pressure signals further revealed a concomitant depression of the activity of all EEG frequency bands (δ, θ, , β), alongside hypotension, negative inotropic and chronotropic actions, and attenuated baroreceptor reflex and vasomotor activity. These effects were congruent with a plasma concentration of propofol in the arterial blood of 1.70 ± 0.13 μg/ml, as determined by high-performance liquid chromatography. |
| Keywords: | Propofol Anesthesia Intravenous infusion Electroencephalogram Noxious thermal stimulation Systemic arterial pressure Power spectral analysis Rat |
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