Overuse of training increases mechanoreceptors in supraspinatus tendon of rats SHR |
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| Authors: | Alberto de Castro Pochini Benno Ejnisman Maria Teresa de Seixas Alves Luiz Fernando Uyeda Viviane Louise Andree Nouailhetas Sang W. Han Moises Cohen Walter Manna Albertoni |
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| Affiliation: | 1. Federal University of S?o Paulo, UNIFESP, S?o Paulo, Brazil;2. Federal University of S?o Paulo, UNIFESP, Brazil;3. Gene Therapy Center, Federal University of S?o Paulo, UNIFESP, Brazil |
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| Abstract: | The presence of mechanoreceptors in tendon after overuse activities can be a further step to learn about tendinopathy and overuse. Studies of tendons mechanoreceptors in rats are rare. We studied 12 isogenic spontaneous hypertensive rats (SHR), which underwent an overuse protocol consisting of an hour per daily session of treadmill running at a speed of 17 m/min, 5 times/week for 4 months. Supraspinatus tendons were evaluated with immunohistochemistry using S100 protein antibodies and histological protocol. Supraspinatus tendons at the end of 4 months of overuse protocol had a high number of media mechanoreceptors (4.3) than controls (0.6). The overexpression of S100 protein antibody in overuse activities maybe could represent a adaptative effort to tendon before the tear. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1771–1774, 2011 |
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| Keywords: | supraspinatus tendon overuse tendinopathy rats tendon overuse mechanoreceptors sports medicine lesions |
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