Radiosynthesis of tritium‐labeled novel nitromethylene neonicotinoids compounds with NaB3H4 |
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| Authors: | Chao Li Xiao‐Yong Xu Ju‐Ying Li Qing‐Fu Ye Zhong Li |
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| Affiliation: | 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, People's Republic of China;2. Institute of Nuclear‐Agricultural Science, Zhejiang University, Hangzhou 310029, Zhejiang Province, People's Republic of China |
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| Abstract: | Paichongding and Cycloxaprid are two novel neonicotinoids with good industrialization prospects for their high activity against imidacloprid‐resistant pest. In this paper, the radiosynthesis of [3H2]‐Paichongding and [3H2]‐Cycloxaprid was achieved using a NaB3H4 reduction. The title compounds were obtained with chemical purities of 98.7 and 98.4%, and radiochemical purities of 97.3 and 98.6%, respectively. The labeled compounds could be used as radiotracers for further study of metabolism and toxicology. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | radiosynthesis tritium‐labeled neonicotinoids NaB3H4 |
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