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| 高脂饮食对脂肪组织Sirtl基因表达影响 | |
| 引用本文： | 白英龙, 李春涛, 刘丹, 姚兴家. 高脂饮食对脂肪组织Sirtl基因表达影响[J]. 中国公共卫生, 2008, 24(5): 575-576. DOI: 10.11847/zgggws2008-24-05-31 |
| 作者姓名： | 白英龙 李春涛 刘丹 姚兴家 |
| 作者单位： | 1.中国医科大学公共卫生学院儿少卫生教研室, 沈阳110001;2.中国医科大学附属第一临床医院信息中心;3.沈阳医学院奉天医院儿科 |
| 摘 要： | 目的 观察高脂肪高能量对脂肪组织酵母染色质沉默因子1基因表达的影响.方法 利用高脂饮食制造肥胖倾向和肥胖抵抗动物模型,采用RT-PCR方法比较皮下和内脏白色脂肪组织SirtlmRNA表达水平.结果 高脂饮食干预导致动物体重生长分化,肥胖倾向组>对照组>肥胖抵抗组,差异有统计学意义(P<0.05);3组动物每日进食量和能量摄入差异有统计学意义(P<0.05);肥胖倾向组大鼠体脂肪含量大于肥胖抵抗组和对照组动物,差异有统计学意义(P<0.05);高脂肪高能量负荷对大鼠脂肪组织Sirtl的表达有抑制作用.结论 Sirtl基因可以作为调控体脂肪含量的靶基因. |
| 关 键 词： | 高脂饮食 脂肪组织 酵母染色质沉默因子1 |
| 文章编号： | 1001-0580(2008)05-0575-02 |
| 收稿时间： | 2007-08-30 |
| 修稿时间： | 2007-08-30 |
Effect of high fat diet on Sirtl expression in fat tissue |
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| BAI Ying-long, LI Chun-tao, Liu Dan, . Effect of high fat diet on Sirtl expression in fat tissue[J]. Chinese Journal of Public Health, 2008, 24(5): 575-576. DOI: 10.11847/zgggws2008-24-05-31 | |
| Authors: | BAI Ying-long LI Chun-tao Liu Dan |
| Affiliation: | 1.Children and Adolescents Health Department, College of Public Health, China Medical University Shenyang 110001, China |
| Abstract: | Objective To observe the effect of hig h fat and high energy intake on silent information regulator1(Sirtl) expression in fat tissue.Methods High fat diet was adopted to stimulate obesity prone(OP)and obesity resist(OR)rat model,and RT-PCR was used to compare the expressive level of Sirtl mRNA.Results Body weight differed in high fat diet fed animals,OP >Control> OR,the difference was significant(P<0.05).Daily food intake and daily energy intake were significantly differ ent as well(P<0.05).OP animals had more body fat than OR and control animals(P<0.05).High fat and high energy intake decrease Sirtl mRNA expression in fat tissue.Conclusion Regulating Sirtl might be potent goal for preventing and treating obesity. |
| Keywords: | high fat die fat tissue Sirtl |
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