基底神经节代谢物的质子磁共振波谱增龄变化

目的 探讨基底神经节代谢物N-乙酰天门冬氨酸/胆碱复合物(NAA/Cho)、N-乙酰天门冬氨酸/肌酸(NAA/Cr)和Cho/Cr浓度比值的增龄变化规律. 方法 选择20～87岁健康志愿者70例,男36例,女34例,分为20～40岁、41～59岁和60～87岁者三组,采用磁共振波谱的二维化学位移成像(2D chemical shift imaging,2D CSI)技术检测其大脑双侧豆状核,丘脑及尾状核的代谢物浓度,分析比较不同年龄组的基底神经节代谢物NAA/Cho、NAA/Cr、Cho/Cr浓度比值的变化.结果 双侧豆状核、尾状核、丘脑的NAA/Cho比值及双侧丘脑、右豆状核的NAA/Cr比值与年龄呈负相关(P<0.05),双豆状核的Cho/Cr比值与年龄呈正相关(P<0.05).不同年龄组的NAA/Cho、NAA/Cr、Cho/Cr比值之间差异亦有统计学意义(P<0.05). 结论 健康人的基底神经节代谢物浓度,随其年龄增长而发牛规律性变化,二维化学位移成像是一种检测基底神经节代谢物浓度的无创伤性的方法,是检测正常脑的生理性和病变脑的病理性代谢物浓度变化的重要手段之一.

Study on proton magnetic resonance spectroscopy in the basal ganglia of elderly people

Objective To assess metabolic alterations in the human basal ganglia area during maturation and aging by using 2D chemical shift imaging (2D CSI) of proton magnetic resonance spectroscopy (1H-MRS). Methods Seventy healthy subjects were examined by 2D CSI. 2D CSI imaging acquisition was performed in the bilateral caudate, lentiform and thalamus. 1H-MRS was processed to determine the metabolite ratios, including NAA/Cho, NAA/Cr, Cho/Cr. Seventy healthy subjects were divided into 3 groups:20 to 39 years of age group, 40 to 59 years of age group and 60 to 87 years of age group. The three groups of healthy participants were compared. Results There was a significant decrease with aging in the NAA/Cho ratio in the bilateral lcntiform, thalamus and left caudate, and a significant decrease with aging in NAA/Cr ratio in the bilateral thalamus,right lentiform and left caudate (P<0.05), whereas the Cho/Cr ratio was significantly increased in the bilateral lentiform with aging(P<0.05). Conclusions The results of 1H-MRS show significant changes in the level of metabolites during the process of aging. This technique may play an important role in clinical studies and applications for various conditions of metabolic disorders of the human brain.