琥珀酸美托洛尔缓释片联合稳心颗粒治疗心肌梗死后室性心律失常临床观察

目的：探讨琥珀酸美托洛尔缓释片联合稳心颗粒治疗心肌梗死后室性心律失常疗效和用药的安全性。方法：将65例心肌梗死后室性心律失常患者随机分为2组：观察组34例采用琥珀酸美托洛尔缓释片和稳心颗粒治疗,对照组31例给予琥珀酸美托洛尔缓释片治疗。比较治疗后2组的动态心电图疗效、症状改善情况,并比较治疗前后2组QT间期离散度改变,同时观察药物的不良反应。结果：治疗4周后,2组症状均有明显改善;观察组室性早搏或阵发室速次数少于对照组;2组QT间期离散度均有下降,且观察组下降程度较对照组更明显。结论：琥珀酸美托洛尔缓释片联合稳心颗粒治疗心肌梗死后室性心律失常临床疗效显著,并能有效预防恶性心律失常,值得临床推广应用。

Clinical Observation on Metoprolol Succinate Sustained-release Tablets Combined with Wenxin Granules Treating Ventricular Arrhythmia after Myocardial Infarction

Objective： To explore the therapeutic effect and safety of Metoprolol Succinate Sustained-release Tablets combined with Wenxin granules in treating ventricular arrhythmia after myocardial infarction. Methods： Sixty five patients with ventricular arrhythmia after myocardial infarction were randomly divided into observation group （ n = 34） and control group （ n = 31） . Patients in the observa- tion group were given Metoprolol Succinate Sustained-release Tablets combined with Wenxin granules,and patients in the control group were treated with Metoprolol Succinate Sustained-release Tablets. Dynamic electrocardiogram,symptom improvement,and QT dispersion changes were compared before and after treatment. Also,adverse reactions of the drugs were observed. Results： After 4 weeks of treatment,symptoms in both groups were improved; the occurrence of ventricular premature beat or ventricular tachycardia were less in observation group compared with the control group; there were decrease of QT dispersion in both groups,and the observation group had more obvious reduction. Conclusion： Metoprolol Succinate Sustained-release Tablets combined with Wenxin granules shows satisfactory therapeutic effect in treating ventricular arrhythmia after myocardial infarction,and it could effectively prevent malignant arrhythmia, which is worth generalizing.