| 高脂血症性胰腺炎大鼠瘦素、瘦素受体表达的动态变化 |
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| 引用本文： | 粱超,冯寿全,张晓云,沙盈盈,朱晓明. 高脂血症性胰腺炎大鼠瘦素、瘦素受体表达的动态变化[J]. 外科理论与实践, 2011, 16(5): 465-469 |
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| 作者姓名： | 粱超 冯寿全 张晓云 沙盈盈 朱晓明 |
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| 作者单位： | 1. 上海中医药大学附属岳阳中西医结合医院普外科,上海,200437
2. 上海中医药大学附属岳阳中西医结合医院病理科,上海,200437 |
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| 摘 要： | 目的:探讨瘦素及瘦素受体在大鼠高脂血症性胰腺炎(HLAP)中的动态变化.方法:将60只SD雄性大鼠随机分为3组:正常对照组(NC组),高脂血症组(HL组),高脂血症性胰腺炎组(HLAP组).采用高脂饲料喂养3周后经腹腔注射L-精氨酸500 mg/100 9体重制作大鼠高脂血症性胰腺炎模型.各组分别于造模后24 h、36...
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| 关 键 词： | 高脂血症性胰腺炎 L-精氨酸 瘦素 瘦素受体 细胞因子 |
Dynamic changes of leptin and leptin receptor expression in hyperlipidemic acute pancreatitis in rats |
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| LIANG Chao,FENG Shou-quan,ZHANG Xiao-yun,SHA Ying-ying,ZHU Xiao-ming. Dynamic changes of leptin and leptin receptor expression in hyperlipidemic acute pancreatitis in rats[J]. Journal of Surgery Concepts & Practice, 2011, 16(5): 465-469 |
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| Authors: | LIANG Chao FENG Shou-quan ZHANG Xiao-yun SHA Ying-ying ZHU Xiao-ming |
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| Affiliation: | LIANG Chaoa,FENG Shou-quana,ZHANG Xiao-yunb,SHA Ying-yinga,ZHU Xiao-minga.a.Department of General surgery,b.Department of Pathology,Yueyang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China |
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| Abstract: | Objective To observe the dynamic changes of leptin and the leptin receptor in hyperlipidemic acute pancreatitis(HLAP)in rats.Methods Sixty SD male rats were randomly divided into 3 groups with 20 rats in each one:(1) normal control(NC) group;(2) hyperlipidemia(HL) group;(3) hyperlipidemic acute pancreatitis(HLAP) group.The HLAP model was made by a single intraperitoneal injection of 500 mg/100 g body weight of L-arginine after feeding with high-fat diet for three weeks.Half of animals in each group were kil... |
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| Keywords: | Hyperlipidemic acute pancreatitis L-arginine Leptin Leptin receptor Cytokine |
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