Effect of repeated partial hepatectomy on cell division in the regenerating rat liver

Repeated partial hepatectomy (PH), performed 24 h after a 70% PH, had the following effect on the mitotic cell cycle in the regenerating rat liver: it delayed (by about 2 h) the cells in the G₂ period, left the S period almost unchanged, and delayed the cells for 6–8 h in the G₁ period. A mock repeated operation had a similar effect. This indicates that the influence of the repeated PH on the mitotic cell cycle in the regenerating liver is due to operation stress. Additional stimulation of division by repeated PH affects the character of the regeneration process as a whole.Laboratory of Chemical Factors of Regulation of Growth and Cell Division, Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. N. Orekhovich.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 10, pp. 488–491, October, 1977.