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| 大鼠牙移动性根吸收组织内钙黏蛋白-11的表达 | |
| 引用本文： | 黑伟红,刘志坚,白丁,郑泽彬,贺红. 大鼠牙移动性根吸收组织内钙黏蛋白-11的表达[J]. 武汉大学学报(医学版), 2012, 33(3): 319-322 |
| 作者姓名： | 黑伟红 刘志坚 白丁 郑泽彬 贺红 |
| 作者单位： | 黑伟红 (广州医学院口腔医院,广东广州,510140) ； 刘志坚 (武汉大学口腔医学院/武汉大学口腔医学院生物医学工程教育部重点实验室,湖北武汉,430079) ； 白丁 (四川大学华西口腔医院正畸科,四川成都,610041) ； 郑泽彬 (汕头大学医学院第一附属医院口腔科,广东汕头,515041) ； 贺红 (武汉大学口腔医学院/武汉大学口腔医学院生物医学工程教育部重点实验室,湖北武汉,430079) ； |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的:检测大鼠牙移动根吸收组织中钙黏蛋白(Cadherin-11)的表达,探讨根吸收过程的分子机制。方法:选用Wistar大鼠建立牙移动根吸收模型;通过TRAP法验证根吸收模型是否成功。通过免疫组化染色,研究Cadherin-11在根吸收组织中的表达。结果:TRAP染色表明,在100g持续力的作用下,大鼠牙根可见明显的吸收;免疫组化分析显示Cadherin-11在根吸收组织中有表达;在一个加力周期中,Cadherin-11的表达随时间渐强。结论:Cadherin-11参与牙根的吸收过程,在根吸收过程中起调节作用。 |
| 关 键 词： | 钙黏蛋白11 牙骨质 正畸诱导性根吸收 |
Expression of Cadherin-11 in Rats Root-Resorption Tissue Induced Orthodontically |
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| HEI Weihong,LIU Zhijian,BAI Ding,ZHENG Zebin,HE Hong. Expression of Cadherin-11 in Rats Root-Resorption Tissue Induced Orthodontically[J]. Medical Journal of Wuhan University, 2012, 33(3): 319-322 | |
| Authors: | HEI Weihong LIU Zhijian BAI Ding ZHENG Zebin HE Hong |
| Affiliation: | 1Stomatology Hospital of Guangzhou Medical College,Guangzhou 510140,China 2School of Stomatology,Wuhan University,Wuhan 430079,China 3Dept.of Orthodontics,West China Stomatology Hospital of Sichuan University, Chengdu 610041,China 4Dept.of Stomatology,The First Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong,China |
| Abstract: | Objective: To investigate the expression of Cadherin-11 in root-resorption tissue and to elucidate the molecular changes and mechanism of root resorption induced by tooth movement.Methods: Wistar rats were subjected to study tooth movement identified by TRAP staining.IHC method was adopted to observe the Cadherin-11 expression.Results: TRAP staining showed obvious root resorption under 100 g sustaining force.Immunohistochemical analysis showed that Cadherin-11 was expressed in the root-resorption tissue in a time-dependant manner within one force cycle.Conclusion: Root resorption model was successfully established.Cadherin-11 is involved in the root resorption process and plays a regulative role. |
| Keywords: | Cadherin-11 Cementum Orthodontic-Induced Root Resorption |
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