Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an <Emphasis Type="Italic">in vitro</Emphasis> study |
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| Authors: | Nina MC Mathijssen Pieter LC Petit Peter Pilot B Wim Schreurs Pieter Buma Rolf M Bloem |
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| Institution: | (1) Netherlands Bone bank Foundation, Rijnsburgerweg 10, 2333 AA Leiden, The Netherlands;(2) Departement of Microbiology, Vlietland Hospital, Vlietlandplein 2, 3118 JH Schiedam, The Netherlands;(3) Department of Orthopaedics, Reinier de Graaf Gasthuis, Reinier de Graafweg 3/11, 2625 AD Delft, The Netherlands;(4) Department of Orthopaedics, UMC St. Radboud, Theodoor Craanenlaan 7, 6525 GH Nijmegen, The Netherlands;(5) Orthopaedic Research Laboratory, Department of Orthopaedics, UMC St. Radboud, Theodoor Craanenlaan 7, 6525 GH Nijmegen, The Netherlands |
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| Abstract: | Background Allograft bone used in joint replacement surgery can additionally serve as a carrier for antibiotics and serve as a prophylaxis
against infections. However, in vitro dose-response curves for bone chips impregnated with different kinds of antibiotics are not available. In addition, while
it would be desirable to add the antibiotics to allograft bone chips before these are stored in a bone bank, the effects of
different storage temperatures on antibiotics are unknown. |
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