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| 甲硝唑阴道用原位凝胶的处方设计及体外质量评价 | |
| 引用本文： | 徐玉红,曾繁涛,王蔓琳,李玉珍,刘新宇,李成. 甲硝唑阴道用原位凝胶的处方设计及体外质量评价[J]. 中国药师, 2008, 11(9) |
| 作者姓名： | 徐玉红 曾繁涛 王蔓琳 李玉珍 刘新宇 李成 |
| 作者单位： | 广东医学院附属福田人民医院,广东深圳,518033 |
| 基金项目： | 深圳市科技计划(医疗卫生类)项目 |
| 摘 要： | 目的:研制甲硝唑阴道用原位凝胶,并考察其体外质量.方法:以卡波姆及泊洛沙姆为混合凝胶基质,筛选其最佳配比,制备甲硝唑阴道用原位凝胶.对其体外流变性、黏附性进行考察,并与上市甲硝唑阴道用凝胶做对照,考察其阴道滞留性.结果:原位凝胶的最佳基质配比为泊洛沙姆407的质量分数为17.5%,卡波姆971P的质量分数为1.5%.黏附力测定结果表明其具有较大的温度敏感性.与上市产品相比,原位凝胶可显著增加阴道滞留性.结论:该原位凝胶具有显著的温度敏感性,本品值得进一步研发. |
| 关 键 词： | 甲硝唑 原位凝胶 泊洛沙姆 制备 体外性质 |
Preparation of Metronidazole in-situ Vaginal Gel and its Properties in Vitro |
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| Xu Yuhong,Zen Fantao,Wang Manlin,Li Yuzhen,Liu Xinyu,Li Cheng. Preparation of Metronidazole in-situ Vaginal Gel and its Properties in Vitro[J]. China Pharmacist, 2008, 11(9) | |
| Authors: | Xu Yuhong Zen Fantao Wang Manlin Li Yuzhen Liu Xinyu Li Cheng |
| Affiliation: | Xu Yuhong Zen Fantao Wang Manlin Li Yuzhen Liu Xinyu Li Cheng(Department of Pharmacy,affiliated Futian People's Hospital,Guangdong Medical College,Shenzhen,518033,China) |
| Abstract: | Objective:To study the preparation of metronidasole in-situ vaginal gel and its properties in vitro.Method:The opti- mal ratio of carbomer 971P and poloxamer 407 was screened to prepare the in-situ gel of metronidasole.The fluidity and adhesion of the gel were studied in vitro.Compared to the marketed product of metrenidazole gel,the vaginal retention of the in-situ gel was also stud- ied.Result:The optimal ratio of poloxamer and carbomer was 17.5% and 1.5%,respectively.The results of the adhesion showed th... |
| Keywords: | Metronidazole In-situ vaginal gel Poloxamer Preparation Property in vitro |
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