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| pRb2/P130与CDK4蛋白在子宫内膜腺癌中的表达及意义 | |
| 引用本文： | 支霜,傅芬,李里香,蔡勇. pRb2/P130与CDK4蛋白在子宫内膜腺癌中的表达及意义[J]. 中国妇幼保健, 2010, 25(1) |
| 作者姓名： | 支霜 傅芬 李里香 蔡勇 |
| 作者单位： | 1. 南昌大学第二附属医院,江西,南昌,330006 2. 江西省肿瘤医院 |
| 摘 要： | 目的:探讨pRb2/P130与CDK4蛋白表达与子宫内膜癌的发生、发展的关系。方法:应用免疫组化S-P法检测pRb2/P130、CDK4在28例正常增生期子宫内膜组织、20例不典型增生子宫内膜、30例子宫内膜腺癌组织中的表达程度,并分析它们之间的关系。结果:pRb2/P130蛋白在正常增生期子宫内膜、不典型增生子宫内膜、子宫内膜腺癌组织中的阳性表达率依次递减,而CDK4的阳性表达率依次递增,子宫内膜腺癌和不典型性增生中pRb2/P130阳性表达率明显低于正常增生期子宫内膜,差异均有统计学意义(P0.05),而CDK4的阳性表达率明显高于正常增生期子宫内膜,差异均有统计学意义(P0.05)。pRb2/P130阳性表达缺失与组织学分级有关(P0.05),与子宫肌层浸润程度无关(P0.05);CDK4阳性表达与子宫内膜腺癌肌层浸润深度有关(P0.05),而与肿瘤的组织学分级和临床分期无关(P0.05)。pRb2/P130蛋白表达与CDK4呈负相关(P0.05)。结论:子宫内膜腺癌中存在pRb2/P130蛋白表达下降或缺失及CDK4的异常表达,促进了细胞的生长和肿瘤的发展,是子宫内膜腺癌的发生、发展中的重要事件。 |
| 关 键 词： | 子宫内膜癌 免疫组织化学 pRb2/P130 CDK4 |
Expression and significance of pRb2/P130 protein and CDK4 protein in endometrial adenocarcinoma |
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| ZHI Shuang,FU Fen,LI Li-Xiang et al. Expression and significance of pRb2/P130 protein and CDK4 protein in endometrial adenocarcinoma[J]. Maternal and Child Health Care of China, 2010, 25(1) | |
| Authors: | ZHI Shuang FU Fen LI Li-Xiang et al |
| Affiliation: | ZHI Shuang,FU Fen,LI Li-Xiang et al.The Second Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China |
| Abstract: | Objective:To explore the relationship between the expression of pRb2/P130 protein and cyclin dependent kinase 4(CDK4) protein and the oncogenesis and development of endometrial adenocarcinoma.Methods:The expression levels of pRb2/P130 protein and CDK4 protein were examined by immunohistochemical S-P method in 28 cases with normal endometrial tissues at proliferative stage,20 cases with endometrial tissues of atypical hyperplasia and 30 cases with endometrial adenocarcinoma,and the relationship among them wa... |
| Keywords: | Endometrial adenocarcinoma Immunohistochemistry pRb2/P130 CDk4 |
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