Lymphopenia in acute nitrofurantoin pleuropulmonary reactions |
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| Authors: | Mario Geller M.D. Dennis K. Flaherty Ph.D. Helen A. Dickie M.D. Charles E. Reed M.D. |
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| Affiliation: | From the Sections of Allergy-Immunology and Chest Medicine, Center for Health Sciences, University of Wisconsin Madison, Wis. U.S.A. |
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| Abstract: | Each of 5 patients with acute nitrofurantoin pleuropulmonary reactions had profound lymphopenia and 4 had eosinophilia developing early in the clinical course after the drug was withdrawn. The 2 patients tested had only one third of the normal numbers of E rosettes (T lymphocytes) in the peripheral blood during recovery. Lymphoblastic transformation tests with purified nitrofurantoin were done in 3 patients and all of them were negative; responses to phytohemagglutinin, concanavalin A, and pokeweed were decreased but still normal. The diagnosis of various nitrofurantoin hypersensitivity reactions relies on clinical data. The mechanisms of these reactions presently remain unclear. |
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| Keywords: | Reprint requests to: Mario Geller M.D. 504 N. Walnut St. Madison Wis. 53706. |
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