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| 新生鼠急性缺氧后脑组织儿茶酚胺含量及超微结构变化的研究 | |
| 引用本文： | 刘文超 柏蕙英. 新生鼠急性缺氧后脑组织儿茶酚胺含量及超微结构变化的研究[J]. 解剖学杂志, 1992, 15(6): 446-449 |
| 作者姓名： | 刘文超 柏蕙英 |
| 作者单位： | 上海第二医科大学解剖教研室，上海第二医科大学解剖教研室，上海第二医科大学解剖教研室，上海第二医科大学解剖教研室 上海，200025，上海，200025，上海，200025，上海，200025 |
| 摘 要： | 将年龄分别为第1、8、15和22天龄的新生大鼠置于5%的低氧环境中2小时,观察其行为变化,并利用高效液相色谱-电化学检测仪测定幼鼠5个脑区(额叶皮质、尾壳核,下丘脑、海马和小脑)内儿茶酚胺神经递质的含量,发现各脑区NE和DA含量呈升高趋势,但第1、8天龄鼠某些脑区含量下降;透射电镜观察发现1、8天龄鼠额叶皮质、尾壳核和海马部分神经元出现线粒体肿胀和空泡样变,细胞间隙扩大,部分细胞核结构破坏,突触小泡的聚集和增多,第15和22天龄鼠脑形态无明显变化. |
| 关 键 词： | 新生鼠 缺氧 脑 儿茶酚胺 超微结构 |
STUDY ON CHANGES OF BRAIN CATECHOLAMINE CONTENT AND BRAIN ULTRASTRUCTURE AFTER ACUTE HYPOXIA OF NEONATAL RATS |
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| Liu Wenchao Shanghai Second Medical University,Shanghai. STUDY ON CHANGES OF BRAIN CATECHOLAMINE CONTENT AND BRAIN ULTRASTRUCTURE AFTER ACUTE HYPOXIA OF NEONATAL RATS[J]. Chinese Journal of Anatomy, 1992, 15(6): 446-449 | |
| Authors: | Liu Wenchao Shanghai Second Medical University Shanghai |
| Affiliation: | Liu Wenchao Shanghai Second Medical University,Shanghai 200025 |
| Abstract: | Rats at age of 1,8,15 and 22 days after birth were exposed to 5% oxygen for 2 hours to expect the change of their behavioral activity,and to measure the contents of catecholamine neurotransmitters in their five brain regions(frontal cortex,caudate nucleus-putamen,hypothalamus,hippocampus and cerebellum) by high performance liquid chromatography-electrochemical detector.The results show that there is a increased tendency of NE and DA contents in the majority brain regions,but the part brain regions where the contents are decreased at age 1 and 8 days.The changes of ultrastructure,found in frontal cortex,caudate nucleus-putamen and hippocampus at the age of day-1 and 8 include:swelling anb vacuolization of mitochondria,enlargment of extracellular space,destroy of part nuclear structures,clumping and increasing of synaptie vesicles,The formations of the brain at the age of day-15,22 are normal, |
| Keywords: | neonaet rat hypoxia brain catecholamine ultrastructure |
| 本文献已被 CNKI 维普 等数据库收录！ | |