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Successful Treatment of Afatinib Reversing Epidermal Growth Factor Receptor Exon19Deletion/G724S Mutation Resistance Guided by Protein-Drug Docking |
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| Authors: | Nian Yu Yinghui Xu Xu Wang Chao Sun Shi Qiu Ye Guo Miao Bai Yanxin Huang Kewei Ma |
| Affiliation: | 1. Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China Co-first authors;2. Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China;3. National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, People's Republic of China |
| Abstract: | |
| Keywords: | Epidermal growth factor receptor G724S mutation Afatinib Non-small cell lung cancer Protein structure remodeling |