Alterations of the dopamine transporter in resting lymphocytes of patients with different psychotic disorders |
| |
| Authors: | Donatella Marazziti Mario Catena Dell'Osso Stefano Baroni Irene Masala Bernardo Dell'Osso Giorgio Consoli Gino Giannaccini Laura Betti Antonio Lucacchini |
| |
| Affiliation: | 1. School of Nursing and Health Studies, University of Miami, 5030 Brunson Drive, Coral Gables, FL 33124, USA;2. Department of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33101, USA;3. Center of Excellence for Health Disparities Research: El Centro, School of Nursing and Health Studies, University of Miami, 5030 Brunson Drive, Coral Gables, FL 33124, USA |
| |
| Abstract: | ![]()
The aim of our study was to investigate and compare the dopamine (DA) transporter (DAT) in resting lymphocytes of 20 psychotic patients and 20 healthy control subjects, by means of both the binding parameters (Bmax and Kd) of 3H-WIN 35,428, and the reuptake parameters (Vmax and Km) of 3H-DA. The results showed that both the Bmax of 3H-WIN 35,428 binding and the Vmax of 3H-DA reuptake of the patients were significantly lower than those of healthy subjects, while the Kd or Km did not show any change. These findings, while indicating a reduced density of the lymphocyte DAT proteins, provide further support of the role of DA in psychoses and suggest that DA alterations may not be limited to brain structures. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
