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AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
Authors:Hung Huynh  Van Chanh Ngo  Heng Nung Koong  Donald Poon  Su Pin Choo  Han Chong Toh  Choon Hua Thng  Pierce Chow  Hock Soo Ong  Alexander Chung  Boon Cher Goh  Paul D. Smith  Khee Chee Soo
Affiliation:1. Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore;2. Department of Surgical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore;3. Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore;4. Department of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore;5. Department of General Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore;6. National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore;7. Cancer and Infection, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK104TG, UK;1. International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, PR China;2. National Center for Liver Cancer Research, Shanghai, PR China;3. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, PR China;1. Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, UMRS-1138, F-75006 Paris, France;2. Functional Genomics of Solid Tumors, USPC, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Immuno-Oncology, équipe labellisée Ligue Contre le Cancer, F-75000 Paris, France;3. Division of Gastroenterology and Hepatology, Department of Internal, Medicine III, Medical University of Vienna, Vienna, Austria;4. Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;5. RPPA Platform, Curie Institute, PSL Research University, Paris, France;6. Bariton INSERM, UMR-1053, Bordeaux, France;7. Department of Pathology, Pellegrin Hospital, Hospital of Bordeaux, Bordeaux, France;8. Anathomopathology Department, Henri Mondor Hospital, Créteil, University of Paris Est Créteil, Inserm U955, Team 18, Mondor Institute of Biomedical Research, Créteil, France;9. Liver unit, Jean Verdier Hospital, University Hospitals Paris-Seine-Saint-Denis, AP-HP, Bondy, France;10. Training and Research Unit of Health Medicine and Human Biology, University of Paris 13, Community of Universities and Institutions Sorbonne Paris Cité, Paris, France;11. European Hospital Georges Pompidou, AP-HP, F-75015, Paris, France;1. Department of Hepatobiliary Surgery and Hepatobiliary Surgical Institute, Chinese PLA General Hospital, Beijing 100853, China;2. State Key Laboratory of Proteomics, China National Center of Biomedical Analysis, 27 Tai-Ping Rd., Beijing 100850, China;3. Department of Hepatobiliary Surgery, NO.401 Hospital of Chinese PLA, Qingdao 266071, Shandong, China;1. School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China;2. State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China;3. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China;4. Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China;5. Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China;1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2. Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;3. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China;4. Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
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