托珠单抗致不良反应文献分析

目的:分析托珠单抗致不良反应(adverse drug reactions,ADRs)发生情况及临床特点,为临床安全用药提供参考.方法:检索Web of Science、PubMed、维普数据库、中国知网数据库和万方数据库关于托珠单抗不良反应的文献并进行分析.结果:托珠单抗致ADRs的个案报道共51例,患者年龄分布以5...

Literature analysis of adverse drug reactions induced by tocilizumab

Objective: To analyze the situation and clinical characteristics of adverse drug reactions( ADRs) induced by tocilizumab,so as to provide references for rational drug use. Methods: Web of Science,Pub Med,Vip,CNKI and Wanfang databases were searched for ADRs induced by tocilizumab,and collected literatures were further analyzed statistically. Results: Fifty-one ADR cases were identified and included. Patients of 51 to 80 years old showed the highest incidence( n = 36,70. 6%). Most cases occurred within 12 months after drug administration( n = 41,80. 4%). The main ADRs induced by tocilizumab were skin and adnexal lesions( n = 11,21. 6%) and gastrointestinal tract lesions( n = 11,21. 6%). The symptoms of 49 patients were cured or improved after withdrawal and/or symptomatic supportive treatment. After the improvement of ADRs,9 patients( 17. 7%) were re-treated with tocilizumab and showed the same ADRs as before. There were also 10 patients( 19. 6%) who did not have ADR after ADRs had improved or recovered. After taking the drug,the monitoring period was 3 months. Conclusion:The benefits and related risks to the patient should be carefully assessed when using tocilizumab in clinic,and the patient’s actual conditions need to be comprehensively considered to prevent serious injury caused by adverse reactions.The patients should be monitored closely to timely find the occurrence of adverse reactions and give timely treatment.Pharmacovigilance investigations are also needed to clarify the long-term safety of tocilizumab.