脂类代谢与结直肠癌发生、发展关系的研究进展

脂类包括脂肪(甘油三酯)和类脂(磷脂、固醇类),提供机体必需脂肪酸和能量.脂类代谢紊乱被认为是包括结直肠癌在内的许多恶性肿瘤的代谢特征.脂类代谢异常会导致细胞膜结构变化、细胞信号传导异常、能量稳态失衡、基因表达和蛋白质分布破坏等分子变化,从而影响细胞增殖、分化、新陈代谢、凋亡以及信息传递等一系列细胞功能.高水平的脂肪酸...

Research progress on the relationship between lipid metabolism and the development of colorectal cancer

Lipids include fats(triglycerides)and lipids(phospholipids and sterols).Lipids provide essential fatty acids and energy for the body.Lipid metabolism disorder is considered to be the metabolic feature of many malignant tumors,including colorectal cancer.Abnormal lipid metabolism will lead to changes in cell membrane structure,abnormal cell signal transduction,imbalance of energy homeostasis,destruction of gene expression and protein distribution,which will affect a series of cell functions such as cell proliferation,differentiation,metabolism,apoptosis and information transmission.Studies have shown that abnormal lipid metabolism is closely related to the occurrence and development of colorectal cancer.High level of fatty acid metabolism is one of the most abnormal metabolic changes of tumor cells.Some lipid metabolic pathways may become potential specific targets for the treatment of colorectal cancer.The relationship between lipid metabolism and the occurrence and development of colorectal cancer,as well as their interaction,is one of the hot spots of tumor nutrition and metabolism.At present,the research results are still controversial and need to be further confirmed by more clinical and basic studies.This paper will systematically elaborate the relationship between lipid metabolism and the occurrence and development of colorectal cancer from three aspects of fatty acid,triglyceride and cholesterol,and inspire the cellular signal and molecular mechanism of interfering with its metabolic pathway,which may provide a new direction for the treatment of colorectal cancer.