前列地尔治疗肺心病并发多脏器衰竭临床研究

目的 探讨前列地尔对肺心病并发多脏器衰竭(MOF)的疗效。方法 对70例患者随机分为A组40例(观察组)，选用前列地尔注射液10～20μg，另给氨茶碱0．25～0．5g，加50％葡萄糖液20～40ml静注，1／d疗程2W。B组不予前列地尔治疗，其余治疗同A组。观察血气(PO、PCO2)、BUN、Cr、CI、EF、神志、呕血、便血、基础情况治疗后A、B两组的变化。结果 A组的显效率及有效率明显高于B组(P＜0．01)，基础情况治疗后A组疗效叫显优于B组(P＜0.01)，但B组间比较无明显改变(P＞0．05)。结论 前列地尔与氨茶碱合用对肺心病并发多脏器衰竭的疗效显著优于单独使用氨茶碱。

Clinical Research of Alprostadil on Patients with Cor Pulmonale Complicated with Multiple Organ Failure(MOF)

Objective To explore the curative effect of alprostadil on patients with pneumocarditis complicated with MOF. Methods Seventy patients with cor pulmonale complicated with MOF were divided into two groups randomly. Fourty patients were selected as group A (experimental group), treated with Alprosstadil and Aminophylline for two weeks. The treatment of group B was the same as group A except alprostadil. Blood gas analysis, blood urea nitrogen (BUN), creatinine (Cr), cardiac output (CI), ejection fraction (EF), consciousness, hematemesis and hematochezia were compared between group A and group B after treatment. Results Effective rate of group A was higher than that of group B (P<0.01). Conclusions The curative effect of Alprostadil and Aminophylline on patients with pneumocarditis complicated with MOF was better than using aminophylline only.