| 萘醌类化合物抗肿瘤活性研究进展 |
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| 引用本文： | 管鹏健,徐德锋,李绍顺. 萘醌类化合物抗肿瘤活性研究进展[J]. 中国药物化学杂志, 2004, 14(4): 249-256 |
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| 作者姓名： | 管鹏健 徐德锋 李绍顺 |
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| 作者单位： | 上海交通大学药学院,上海,200030 |
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| 摘 要： | 萘醌类化合物是一类天然生物活性分子,多数具有抗肿瘤作用.随着该类化合物抗肿瘤作用及其机理的深入研究和逐步阐明,人们合成了许多萘醌衍生物.根据萘醌母体结构的不同,这些化合物可分为萘茜类、1,4-萘醌类和1,2-萘醌类等.本文综述了近年来此类化合物抗肿瘤作用、作用机理、构效关系等研究的新进展.
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| 关 键 词： | 药物化学 构效关系 综述 萘醌 抗肿瘤 |
| 文章编号： | 1005-0108(2004)04-0249-08 |
Advances in the antitumor activitis of naphthoquinones |
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| GUAN Peng-jian,XU De-feng,LI Shao-shun. Advances in the antitumor activitis of naphthoquinones[J]. Chinese Journal of Medicinal Chemistry, 2004, 14(4): 249-256 |
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| Authors: | GUAN Peng-jian XU De-feng LI Shao-shun |
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| Abstract: | Naphthoquinones are a series of natural bioactive molecules,most of which have antitumor effects.There are a lot of researches on their activities and mechanisms.Many derivatives of naphthoquinones have been synthesized,and their structure-activity relationships(SARs)were studied.Due to the different parent rings of these compounds,they are classified into naphthazarins(5,8-dihydroxy-1,4-naphthoquinones),1,4-naphthoquinones,1,2-naphthoquinones,and so on.Recent progresses of their antitumor activities,mechanisms and SARs are summarized in this review. |
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| Keywords: | medicinal chemistry structure-activity relationship review naphthoquinones antitumor action |
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