| 树突细胞与哮喘Th1/Th2失衡 |
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| 引用本文： | 刘国梁,林耀广. 树突细胞与哮喘Th1/Th2失衡[J]. 基础医学与临床, 2004, 24(4): 361-365 |
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| 作者姓名： | 刘国梁 林耀广 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,北京协和医院,呼吸内科,北京,100730;中国医学科学院,中国协和医科大学,北京协和医院,呼吸内科,北京,100730 |
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| 摘 要： | 特应性哮喘患者以Th2免疫反应为主，导致气道炎症，Th1／Th2失衡是特庆性哮喘重要的免疫病理机制，树突细胞（DCs）中肺部主要抗原递呈细胞，不但可以介志对吸入抗原初始的免疫反应，活化辅助性T细胞，而且在可以决定T细胞的分化方向，维持哮喘Th2免疫反应和Th1／Th2失衡机制中发挥重要作用而日益受到重视。本文就近年来对特应性哮喘免疫病理机制中DCs对Th1／Th2失衡影响认识作一综述。
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| 关 键 词： | 树突细胞 Th1/Th2 特应性哮喘 |
| 文章编号： | 1001-6325(2004)04-0361-05 |
| 修稿时间： | 2004-06-15 |
Dendritic cells and Th1/Th2 immune response in allergic asthma |
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| LIU Guo-liang,LIN Yao-guang. Dendritic cells and Th1/Th2 immune response in allergic asthma[J]. Basic Medical Sciences and Clinics, 2004, 24(4): 361-365 |
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| Authors: | LIU Guo-liang LIN Yao-guang |
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| Abstract: | Th2 immune response mediates the airway inflammation in allergic asthma and the imbalance of Th1/Th2 is the important immunological pathogenesis of allergic asthma. However, dendritic cells are the most important antigen-presenting cell in the lung, which can not only induce the primary immune response to antigen reaching the airways and activate helper T cells but also determine Th polarisation. Therefor, dendritc cells are of increasing interest because of their important role as regulators of the immune response. In this review artical, we discuss the most recent findings on the dendritic cells and Th1/Th2 immune response in allergic asthma. |
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| Keywords: | dendritic cells Th1/Th2 allergic asthma |
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