| 神经元型一氧化氮合酶在心脏功能调节中的作用 |
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| 引用本文： | 张一帅,杨晶,彭军,李元建,胡长平. 神经元型一氧化氮合酶在心脏功能调节中的作用[J]. 中国药理学通报, 2009, 25(3) |
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| 作者姓名： | 张一帅 杨晶 彭军 李元建 胡长平 |
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| 作者单位： | 中南大学药学院药理学系,湖南,长沙,410078 |
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| 摘 要： | 神经元型一氧化氮合酶(nNOS)不仅在神经细胞中表达,也存在于心肌细胞。生理状况下,nNOS源性的一氧化氮(NO)通过自分泌以负反馈的调节方式维持细胞内Ca2+浓度稳态,防止细胞内Ca2+浓度超载,对于维持正常的心功能具有重要意义。病理状况下,nNOS的活性发生明显变化,nNOS源性的NO可能参与了心脏疾病的发生和发展。
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| 关 键 词： | 一氧化氮 一氧化氮合酶 神经源性一氧化氮合酶 心功能 |
The role of neuronal nitric oxide synthase in the regulation of cardiac function |
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| ZHANG Yi-shuai,YANG Jing,PENG Jun,LI Yuan-jian,HU Chang-ping. The role of neuronal nitric oxide synthase in the regulation of cardiac function[J]. Chinese Pharmacological Bulletin, 2009, 25(3) |
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| Authors: | ZHANG Yi-shuai YANG Jing PENG Jun LI Yuan-jian HU Chang-ping |
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| Abstract: | Neuronal nitric oxide synthase(nNOS)expresses not only in neural cells,but also in cardiomyocytes.Under physiological condition,nNOS-derived nitric oxide(NO)participates in maintaining the stability of intracellular [Ca2+] by autocrine action through the manner of negative feedback,and in turn prevents cells from Ca2+ overload.Therefore,nNOS plays an important role in keeping normal cardiac function.Under pathological condition,there are significant changes in the activity of nNOS,and nNOS-derived NO may involve in the genesis and development of heart diseases. |
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| Keywords: | nitric oxide nitric oxide synthase neuronal nitric oxide synthase cardiac function |
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