枸橘药材的本草考证及质量分析

目的:通过对枸橘药材的研究,分析枸橘药材药用历程和质量标准,为其质量评价提供科学依据。方法:通过查阅文献与实地调查,从名称、药用历史及地理分布3方面完成对枸橘药材的本草考证;运用薄层色谱法,HPLC对枸橘、枳实及枳壳中的辛弗林、柚皮苷、橙皮苷及新橙皮苷进行定性及定量分析。辛弗林参考2015年版《中国药典》中枳实的含量测定方法,柚皮苷、橙皮苷及新橙皮苷参考2015年版《中国药典》中枳壳的含量测定方法。结果:本草考证得知,枸橘在历史上最早作枳实使用,宋朝时期枸橘果实不再作为枳实与枳壳的唯一正品来源,明清时期枸橘与枳实、枳壳明确区分开来,酸橙果实成为枳实与枳壳的正品来源至今;质量分析得到,枸橘中含有辛弗林、柚皮苷、橙皮苷及新橙皮苷,但含量较枳实、枳壳低,枳实、枳壳中指标性成分均符合2015年版《中国药典》标准。结论:枸橘药材曾作为枳实和枳壳的正品来源,该研究得出枸橘具有枳实和枳壳相同的指标成分,为开发新的药用资源提供了参考依据。

Herbal Textual Research and Quality Analysis of Poncirus Herbs

Objective: Through research on Poncirus Herbs,analysis process of poncirin and quality standards, provide the scientific basis for quality evaluation. Method: Literature review and field survey twere used to study the herbal textual of Poncirus Herbs, and qualitative analysis the synephrine,naringin,hesperidin and neohesperidin in Poncirus Herbs,Aurantii Fructus Immaturus and Aurantii Fructus were conducted by thin layer chromatography and HPLC. Result: In the history of the first herbs for Aurantii Fructus Immaturus use,the Song Dynasty is not the only authentic source of Poncirus Herbs. During the Ming and Qing dynasties,the genuine source of Aurantii Fructus Immaturus and Aurantii Fructus is Citrus aurantium contains synephrine,naringin,hesperidin and neohesperidin, but low content,the index components in Aurantii Fructus Immaturus and Aurantii Fructus, are in line with the 2015 edition of Chinese Pharmacopoeia standard. Conclusion: From the herbal textual study,we find Poncirus Herbs have been used as the authentic source of Aurantii Fructus Immaturus and Aurantii Fructus,and have the same index components of Aurantii Fructus Immaturus and Aurantii Fructus, which provide a reference for the development of new medicinal resources.