紫杉醇联合5-氟尿嘧啶、亚叶酸钙方案治疗晚期胃癌近期疗效评价

 目的 评价含紫杉醇（TAX）联合5-氟尿嘧啶（5-Fu）、亚叶酸钙（LV）组成的TF方案治疗晚期胃癌的临床疗效及安全性。方法 55例病理证实的晚期胃癌患者接受TF方案治疗，21 d为1周期，连用2 ~ 3个周期后评价疗效。结果 55例患者均可评价疗效及毒副作用，有效率为45.45 %。临床受益反应（CBR）35例可评价，疼痛缓解率为86.6 %，Karnofsky评分增加≥20分者占56.4 %。白细胞数减少发生率为56.4 %，Ⅲ度以上占10.9 %。胃肠道反应发生率为43.6 %。结论 TF方案治疗晚期胃癌疗效确切，CBR高，不良反应可以耐受，对多次使用含5-Fu及衍生物方案治疗过的患者仍有一定疗效。

Clinical study on taxol plus 5-fluorouracil/leucovorin combination chemotherapy for patients with advanced gastric cancer

Objective The current study was designed to evaluate the efficacy and toxicity of taxol plus fluorouracil(TF) chemotherapy in patients with advanced gastric cancer. Methods 55 patients with ad－vanced gastric cancer were treated with TF schedule. A treatment cycle lasted 21 days. The efficacy was eval－uated after 2~3 cycles of the chemotherapy. Results These 55 patients were evaluated the efficacy and the toxicity. The total efficiency rate of TF schedule was 45.45 %. Clinical Benefit Response (CBR)were evaluated in 35 patients. Ache remission rate was 86.6 %. The main side effect of toxicity was neutropenia. The total re－sponse neutropenia is 56.4 %. The above Ⅲ stage was 10.9 %. The rate of nausea and vomiting was 43.6 %. Conclusion The combination of taxol and fluorouracil is a high response protocol with mild toxicity.TF schedule has high efficiency for advanced gastric cancer, especially for the patients who had had chemothera－py with fluorouracil.