三种药物联合注射治疗口腔颌面部静脉畸形350例疗效分析

目的总结分析平阳霉素(PYM)、地塞米松(DXM)和鱼肝油酸钠(SM)联合瘤内注射治疗口腔颌面部海绵状血管瘤(静脉畸形)的临床疗效。方法选取口腔颌面部静脉畸形350例,采用PYM、DXM、SM三药联合注射治疗。用DXM5mg/1ml,配PYM8mg,加1%普鲁卡因注射液4ml,按体表瘤体面积每1cm×1cm注射1ml混合液计算剂量,进行瘤体内注射,再按相对大剂量鱼肝油酸钠注射方法继续注射鱼肝油酸钠。每隔5～7d注射1次,3～5次为1个疗程。未愈者可重复联合治疗。结果治疗后经6～48个月随访,治愈246例(70.29%),基本治愈88例(25.14%),好转16例(4.57%),有效率为100%。结论PYM、DXM、SM联合注射治疗口腔颌面部静脉畸形,具有疗程短、不良反应小等优点,是一种安全、可靠、简便的治疗方法。

The Effect of Pinyangmycin, Dexamethasonum and SodiumMorrhuate Injected Concomitantly to Treat Cavernous Hemangioma

OBJECTIVE: The effect of Pinyangmycin, Dexamethasonum and Sodium Morrhuate injected concomitantly to treat cavernous hemangioma in oral and maxillofacial regions was evaluated. METHODS: The medical records of 350 patients with cavernous hemangioma in oral and maxillofacial regions between January 1998 and January 2002 were reviewed. One hundred and sixty-five of the patients were men, and 185 were women, the sex ratio was 1:1.12. The patients' ages were between 4 months and 55 years. Two hundred and Twenty-six hemangiomas were located in the maxillofacial regions, and 124 located in the oral cavity. The size of the lesions varied from 1 cm x 1 cm to 6 cm x 9 cm. Pinyangmycin, Dexamethasonum and Sodium Morrhuate were injected simultaneously into the lesions or in the vicinity of the cavernous hemangiomas, and the injection might be repeated every 5 to 7 days when necessary, and this process could be repeated 3 to 5 times. RESULTS: Three hundred and fifty patients were followed up for 6-48 months. The cure and essentially cured rates were 95.48%, the total efficiency rate was 100%. CONCLUSION: This method was a safe, simple and effective therapy to manage cavernous hemangioma in the oral and maxillofacial regions.