|
|||||
|
|
| 表皮葡萄球菌对氟喹诺酮类药物摄入的研究 | |
| 引用本文： | 何汉江 谭立志 李丽华 周芸 陆春雪 曾焱华. 表皮葡萄球菌对氟喹诺酮类药物摄入的研究[J]. 中国感染与化疗杂志, 2005, 5(2): 92-95 |
| 作者姓名： | 何汉江 谭立志 李丽华 周芸 陆春雪 曾焱华 |
| 作者单位： | [1]湘南学院基础医学部微生物学教研室，湖南郴州423000 [2]南华大学微生物教研室 |
| 摘 要： | 目的探讨耐药表皮葡萄球菌中是否存在主动外排系统，以揭示表皮葡萄球菌对氟喹诺酮类药物的耐药机制。方法应用荧光法检测表皮葡萄球菌耐药株和敏感株对环丙沙星、司帕沙星的累积量以及加入利血平和碳酰氰间氯苯腙(CCCP)后对环丙沙星、司帕沙星累积量的变化情况。结果表皮葡萄球菌临床株和敏感株中加入CCCP后菌体内环丙沙星、司帕沙星的累积量变化不大．而利血平可以使SR79菌体内环丙沙星的累积量显上升。结论表皮葡萄球菌中可能存在针对亲水性氟喹诺酮药物的主动外排系统。 |
| 关 键 词： | 表皮葡萄球菌 氟喹诺酮类药物 主动外排系统 |
| 文章编号： | 1009-7708(2005)02-0092-04 |
| 修稿时间： | 2004-08-03 |
Study on uptake of fluoroquinolones by Staphylococcus epidermidis |
|
| HE Han-jiang,TAN Li-zhi,LI Li-hua,ZHOU Yun,LU Chun-xue,ZENG Yan-hua.. Study on uptake of fluoroquinolones by Staphylococcus epidermidis[J]. Chinese Journal of Infection and Chemotherapy, 2005, 5(2): 92-95 | |
| Authors: | HE Han-jiang TAN Li-zhi LI Li-hua ZHOU Yun LU Chun-xue ZENG Yan-hua. |
| Abstract: | Objective To explore whether active efflux system is present in Staphylococcus epidermidis in order to identify the resistance mechanism of S.epidermidis to antibiotics.Methods The accumulation of ciprofloxacin and sparfloxacin in S.epidermidis were measured by a fluorescence method and the influence of carbonyl cyanide m-chlorophenylhydrazone (CCCP) or reserpine was analyzed.Results Reserpine could dramatically increase the accumulation of ciprofloxacin in S.epidermidis SR79. However, CCCP had little effect on the accumulation of ciprofloxacin and sparfloxacin in clinical susceptible S. epidermidis isolates. Conclusions There may have an active efflux system targeting hydrophilic fluoroquinolones in S.epidermidis. |
| Keywords: | Staphylococcus epidermidis Fluoroquinolones Active efflux system |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |