中西医结合治疗慢性尿酸性肾病的临床研究

目的:观察中西医结合治疗慢性尿酸性肾病的临床疗效。方法:136例慢性尿酸性肾病患者随机分成两组,治疗组86例根据中医辨证分型以中药加别嘌呤醇治疗,对照组50例单纯以别嘌呤醇治疗,观察两组治疗前后血尿酸、肾功能、尿蛋白、尿系列微量蛋白、血脂及血液粘度指标的变化。结果:治疗组总有效率为90.70％,明显高于对照组56％的总有效率(P<0.01);且治疗组在改善症状及肾功能,降低血尿酸、蛋白尿和尿系列微量蛋白,改善血脂代谢及血液高凝状态等方面均明显优于对照组(P<0.01或P<0.05)。结论:中西医结合治疗能明显提高慢性尿酸性肾病的临床疗效。

Clinical Study of Treatment on Chronic Uric Acid Nephropatyy by Integrating Western and Traditional Chinese Medicine

Objective:To investigate the ameliorative effect on chronic uric acid nephropathy (CUAN) by integrating western and traditional Chinese medicine (IWTCM) . Methods:The 136 CUAN patients were divided into two groups at random,the therapy group of 86 patients were treated by Chinese medicine and allopurinol,and the control group of 50 patients were treated only by allopurinol. The curative effect and the related index such as blood uric acid,renal function,urinary protein,microproteins,blood lipid and hyperviscosity were determined before and after being treated.Results: After three months treatment,the total effective rate in the therapy group (90.7%) was significantly higher (P <0.0l) than that of the control group (56%). The therapy group is also superior to the control group in improving renal function,lipid metabolism and hyperviscosity,decreasing blood uric acid,urinary protein,microproteins in evidence (P<0.05,P<0.01). Conclusion: I-WTCM can obviously improve the ameliorative effect on chronic uric acid nephropathy.