心肾综合征患者血清NT-ProBNP浓度、心脏不良事件、短期再住院率与单纯心衰患者的差异性分析

目的：比较心肾综合征（合并肾衰的心衰）患者血清氨基末端B型利钠肽前体（NT-ProBNP）浓度、心脏不良事件、短期再住院率与单纯心衰患者的差异性。方法随机纳入120例充血性心力衰竭（CHF）患者，采集肘静脉血，检测SCr与NT-ProBNP浓度，据血清SCr浓度分为SCr升高组（心肾综合征组）与SCr正常组（单纯心衰组），观察所有患者住院期间心脏不良事件的发生情况，并随访其30天再住院情况。结果与血清SCr正常组相比，血清SCr升高组NT-ProBNP浓度明显升高，分别为32．86（21．23-61．57）ng/ml和21．52（12．01-35．24）ng/ml；住院期间心脏不良事件发生率显著升高，分别为26．67％和3．33％；患者30天再住院率明显升高，分别为35．0％和13．3％；两组比较，均有显著性差异（P＜0．05）。结论心肾综合征患者血清NT-ProBNP浓度明显升高，其心脏不良事件发生率和30天再住院率亦较单纯心衰组明显升高。

Difference Analysis of serum concentrations of NT-ProBNP,adverse cardiac events,short-term readmission rates for pa-tients with Cardiorenal syndrome and heart failure alone

Objective Comparison of serum concentrations of NT-ProBNP,adverse cardiac events,short-term read-mission rates for patients with Cardiorenal syndrome and heart failure alone.Methods Totally of 120 patients with heart failure were enrolled.Collected venous blood of elbow,The blood concentration of NT-ProBNP and SCr were de-termined by using fluorescence immunoassay （FIA）.It is divided into SCr increased group（Cardiorenal syndrome）and the normal SCr group（heart failure alone）according to Serum creatinine concentration.The incidence of adverse cardiac events was observed during the period of in-hospital and The 30-day rehospitalization rate was determined by following-up.Results Compared with the normal serum SCr group,the serum concentrations of NT-ProBNP were significantly higher in the serum SCr increased group,which were 32.86 （21.23-61.57）ng/ml and 21.52 （12.01-35.24）ng/ml. The incidence of adverse cardiac events of the serum SCr increased group was significantly higher,which were 26.67%and 3.33%.The 30-day readmission rates was aslo significantly higher,which were35.0% and 13.3%.The difference of the two groups was all statistically significant （P〈0.05）.Conclusion The serum concentrations of NT-ProBNP were significantly higher in patients of Cardiorenal syndrome.The incidence of adverse cardiac events and The 30-day rehospitalization rate were also significantly higher.