|
|||||
|
|
| 文拉法辛联合治疗方案对难治性抑郁症疗效的随机对照研究 | |
| 引用本文： | 高代林,徐佳军,毕建强,舒建民,张郭莺,杨彦春,孙学礼. 文拉法辛联合治疗方案对难治性抑郁症疗效的随机对照研究[J]. 中华精神科杂志, 2009, 42(3): 146-148. DOI: 10.3760/cma.j.issn.1006-7884.2009.03.008 |
| 作者姓名： | 高代林 徐佳军 毕建强 舒建民 张郭莺 杨彦春 孙学礼 |
| 作者单位： | 1. 深圳市精抻卫生中心临床心理科 2. 四川大学华西医院心理卫生中心,成都,610041 |
| 基金项目： | 国家"十五"科技攻关资助项目 |
| 摘 要： | Objective To compare the efficacy of venlafaxine combination of cognitive behavior therapy or lithium or olanzapine for treatment-resistant depression. Method A prospective stratified randomized controlled clinical trial were adopted to the patients with treatment-resistant depression. 69 cases were divided into three groups with random number table, each group including 23 cases. One group was with venlafaxine combination of cognitive behavior therapy, others with combination of lithium, or olanzapine, for 6 weeks to observe the efficacy. The major indexes for therapeutic effects was Hamilton Depression Scale (HAMD) reducing score rate. Results The differences were significant in HAMD reducing score rate between the group with combination of cognitive behavior therapy[(61±5) %] and the group with combination of lithium [( 54 ± 7 ) %] ( t = 8.90, P < 0. 05 ), or olanzapine [( 47 ± 6 ) %] ( t =3.46,P < 0.05 ), with no significant difference is between the group with combination of lithium and the group with combination of olanzapine. Conclusion The total efficacy of venlafaxine combination of cognitive behavior therapy is superior to venlafaxine combination of lithium or olanzapine for treatmet-resistant depression. |
| 关 键 词： | 抑郁症 认知疗法 行为疗法 文拉法辛 |
A randomized controlled clinical trial of the combination of venlafaxine for treatment-resistant depression |
|
| Abstract: | Objective To compare the efficacy of venlafaxine combination of cognitive behavior therapy or lithium or olanzapine for treatment-resistant depression. Method A prospective stratified randomized controlled clinical trial were adopted to the patients with treatment-resistant depression. 69 cases were divided into three groups with random number table, each group including 23 cases. One group was with venlafaxine combination of cognitive behavior therapy, others with combination of lithium, or olanzapine, for 6 weeks to observe the efficacy. The major indexes for therapeutic effects was Hamilton Depression Scale (HAMD) reducing score rate. Results The differences were significant in HAMD reducing score rate between the group with combination of cognitive behavior therapy[(61±5) %] and the group with combination of lithium [( 54 ± 7 ) %] ( t = 8.90, P < 0. 05 ), or olanzapine [( 47 ± 6 ) %] ( t =3.46,P < 0.05 ), with no significant difference is between the group with combination of lithium and the group with combination of olanzapine. Conclusion The total efficacy of venlafaxine combination of cognitive behavior therapy is superior to venlafaxine combination of lithium or olanzapine for treatmet-resistant depression. |
| Keywords: | Depressive disorderCognitive therapyBehavior therapyVerdafaxine |
| 本文献已被 万方数据 等数据库收录！ | |