前列腺素E1对2型糖尿病合并冠心病患者血液流变学的影响

目的:研究2型糖尿病合并冠心病患者血液流变学改变及其前列腺素E1治疗对其的影响.方法:对86例2型糖尿病患者(其中合并冠心病患者53例,单纯糖尿病患者33例)进行血液流变学指标检测,并与对照组比较,2型糖尿病合并冠心病患者采用前列腺素E1治疗,观察其血液流变学的改变.结果:与对照组相比,2型糖尿病患者的全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白原、红细胞聚集指数和血小板聚集率均明显升高(P＜0.05),红细胞变形指数明显降低(P＜0.05),其中糖尿病合并冠心病组变化更为显著(P＜0.05).前列腺素E1可以明显降低糖尿病合并冠心病患者的血液黏度和血小板聚集率(P＜0.05).结论:2型糖尿病合并冠心痛患者的血液黏度和血小板聚集性增高,前列腺素E1可以明显改善血流动力学和微循环.

Effect of prostaglandin E1 on hemorheology in type 2 diabetic patients with coronary heart disease

Objective To investigate the hemorheological changes in type 2 diabetic patients with coronary heart disease and the effect of prostaglandin E1 on those changes.Methods We measured the hemorheological parameters in 53 type 2 diabetic patients with coronary heart disease and 33 patients with type 2 diabetes mellitus alone.The data were compared with those from the control group.The patients with type 2 diabetes mellitus and coronary heart disease were administered with prostaglandin E1 and their hemorheological changes were observed.Results Whole blood viscosity,plasma viscosity,plasma fibrinogen,erythrocyte aggregation index,and platelet aggregation rate were significantly elevated while erythrocyte deformability was markedly decreased in the type 2 diabetic patients,and more evidently in those with coronary heart disease(P< 0.05),as compared with those in the control group.A noticeable decrease in blood viscosity and platelet aggregation rate occurred in the type 2 diabetic patients with coronary heart disease receiving prostaglandin E1(P< 0.05).Conclusions Blood viscosity and platele aggregation ability are significantly elevated in type 2 diabetic patients with coronary heart disease.Prostaglandin E1 may improve the hemorheology and microcirculation in those patients.