Modified Ferriman-Gallwey hirsutism score and androgen levels in Turkish women |
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Authors: | Coskun Ayhan Ercan Onder Arikan Deniz Cemgil Özer Ali Kilinc Metin Kiran Gurkan Kostu Bulent |
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Affiliation: | a Kahramanmaras Sutcuimam University, Medical Faculty, Department of Obstetrics and Gynecology, Kahramanmaras, Turkey b Ministry of Health, Ankara Etlik Zübeyde Han?m Maternity and Women's Health Research Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey c Kahramanmaras Sutcuimam University, Medical Faculty, Department of Public Health, Kahramanmaras, Turkey d Kahramanmaras Sutcuimam University, Medical Faculty, Department of Biochemistry, Kahramanmaras, Turkey e Ministry of Health, Sereflikochisar State Hospital, Department of Obstetrics and Gynecology, Ankara, Turkey |
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Abstract: |
Objective(s)To evaluate a modified Ferriman-Gallwey (mFG) scoring system and serum total testosterone (tT) and dehydroepiandrosterone sulfate (DHEAS) levels, in women with polycystic ovary syndrome (PCOS) and in control subjects.Study designWomen with any gynecological problem who presented to the Kahramanmaras Sutcuimam University Medical Faculty Gynecology and Obstetric Outpatient Clinic in the Mediterranean region of Turkey were assessed prospectively. Oligo-anovulation, clinical and biochemical hyperandrogenism, and PCO appearance on ultrasound that met the 2003 Rotterdam Consensus Criteria were used for PCOS diagnosis. Group 1 consisted of 43 cases with a diagnosis of PCOS and group 2 (control group) consisted of 75 age and BMI matched control subjects without PCOS.ResultsIn groups 1 and 2, clinical hyperandrogenism (hirsutism) appearance ratio was 86.0% (37/43) and 18.0% (15/75) (p < 0.001); while biochemical hyperandrogenism (high serum tT or DHEAS level) was 65.1% (28/43) and 36% (27/75) (p < 0.05), respectively. In groups 1 and 2, mean serum tT levels were 115.2 and 73.4 ng/dL (p < 0.001), mean serum DHEAS levels were 256.1 and 177.7 ng/dL (p < 0.001), and mean hirsutism scores were 11.2 and 5.5 (p < 0.001), respectively. Serum mean tT, DHEAS and hirsutism scores for group 1 were significantly higher than those of group 2 (<0.001). No correlation was observed between BMI and the hirsutism scores or the biochemical hyperandrogenism in both groups.Conclusion(s)In our study, mean serum androgen levels and hirsutism ratio in the PCOS group were higher than the control group. These values were also substantially higher than those previously published in the literature. |
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Keywords: | Hirsutism Modified Ferriman-Gallwey scoring system Total testosterone Dehydroepiandrosterone sulfate Turkish women |
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