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Anti-Helicobacter pylori antibodies in cervical mucus: a new cause of infertility
Authors:Ambrosini Guido  Andrisani Alessandra  Fiore Cristina  Faggian Diego  D'Antona Donato  Ragazzi Eugenio  Plebani Mario  Armanini Decio
Affiliation:a Department of Gynecological and Human Reproductive Sciences, University of Padova, Italy
b Department of Medical and Surgical Sciences, Endocrinology, University of Padova, Via Ospedale 105, 35128 Padova, Italy
c Department of Laboratory Medicine, University of Padova, Italy
d Department of Pharmacology and Anesthesiology, University of Padova, Italy
Abstract:

Objective

The aims of our study were to determine on the one hand a correlation between the presence of anti-Helicobacter pylori (anti-H. pylori) IgG antibodies in serum and cervical mucus of women with idiopathic infertility, and on the other hand the effect of these antibodies on cervical mucus quality, in particular related to the ability of spermatozoa to penetrate it.

Study design

We analysed anti-H. pylori IgG antibodies in the serum and cervical mucus of 67 patients diagnosed with idiopathic infertility using the Quanta Lite H. pylori IgG test. The penetration of normal sperm, in 15 cervical mucus samples positive for anti-H. pylori antibodies and in 15 negative samples, was assessed using the simplified slide test.

Results

A significant positive correlation emerged between anti-H. pylori IgG antibody concentrations in the serum and in the cervical mucus (r = 0.9275; p < 0.00001). In the 15 anti-H. pylori IgG mucus-positive samples the slide test showed abnormal penetration by the spermatozoa.

Conclusions

Our study demonstrated that the presence of anti-H. pylori antibody in the cervical mucus can be involved in female infertility, interfering with sperm progression. Considering the close correlation found between serum and cervical mucus anti-H. pylori antibody titres, measuring serum antibodies could become an additional test, in particular in couples with unexplained infertility.
Keywords:Anti-Helicobacter pylori IgG antibodies   Cervical mucus   Idiopathic infertility   Sperm-cervical mucus interaction
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