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| 盐酸格拉司琼喷剂质量分析 | |
| 引用本文： | 周继法,刘利根. 盐酸格拉司琼喷剂质量分析[J]. 中国中医药现代远程教育, 2012, 0(19): 161-163 |
| 作者姓名： | 周继法 刘利根 |
| 作者单位： | 1. 江苏省中医院,南京210029 2. 中国药科大学,南京210009 |
| 摘 要： | 目的研究盐酸格拉司琼喷剂质量控制方法 ,为制订质量标准提供技术依据。方法采用HPLC法测定含量,并控制每瓶总喷次和每喷主药含量。色谱柱为氰基硅烷键合硅胶柱;流动相：含0.25%（mLmL-1）三乙胺的0.05molL-1醋酸钠溶液-甲醇（50：50）;检测波长：302nm。结果盐酸格拉司琼浓度在22～114μgmL-1范围内线性关系良好,回收率为100.13%,RSD为0.90%。结论所建立质量控制方法合理、可靠,重复性好,可用于盐酸格拉司琼喷剂的质量控制。 |
| 关 键 词： | 盐酸格拉司琼 含量测定 高效液相色谱法 |
Quality Analysis of Granisetron Hydrochloride Spray |
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| Zhou Jifa,Liu Ligen. Quality Analysis of Granisetron Hydrochloride Spray[J]. Chinese Medicine Modern Distance Education of China, 2012, 0(19): 161-163 | |
| Authors: | Zhou Jifa Liu Ligen |
| Affiliation: | 1 Jiangsu Province Hospital of Traditional Chinese Medicine,Nanjing 210029,China;2 China Pharmaceutical University,Nanjing 210029,China) |
| Abstract: | Objective Granisetron hydrochloride spray quality control methods, to provide the technical basis, for the development of quality standards. Methods HPLC determination of content, detecting the total spray times in each bottle and testing each spray drug content. The chromatographic column was cyanosilane bonded silica gel column; mobile phase containing 0.25% （mL.mL-1） triethylamine in 0.05 tool.L-1 sodium acetate solution-methanol （50：50）; detection wavelength： 302 nm. Rosults Granisetronhydrochloridein22-1141μomL-1 concentration range was linear relationship, recovery 100.13 %, RSD 0.90 %. Conclusions Established a reasonable method of quality control, reliable, reproducible and can be used for quality control of granisetron hydrochloride spray. |
| Keywords: | Granisetron hydrochloride Content determination HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |