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Mood state and cerebral metabolism in persons with age-associated memory impairment |
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| Authors: | Monique M Cherrier Gary W Small Scott Komo and Asenath La Rue |
| Institution: | a Department of Psychiatry and Behavioral Sciences, Box 358280, GRECC 182B, University of Washington School of Medicine, Seattle, WA 98195, USA b Department of Psychiatry and Biobehavioral Sciences, UCLA, School of Medicine, Neuropsychiatric Institute and Hospital, 760 Westwood Plaza, Los Angeles, CA 90024, USA |
| Abstract: | People undergoing medical procedures sometimes experience feelings that may influence the results. In this study, we explore the relationship between changes in mood state self-ratings and cerebral glucose metabolism during positron emission tomography (PET) in persons with age-associated memory impairment (mean age 59.4±9.8 years). Brain regions of interest involved in both mood and memory were examined. Mood ratings of increased boredom correlated significantly with mesial temporal and parietal asymmetry and decreased parietal metabolism. Mood ratings of increased fatigue correlated with basal ganglia asymmetry and the right basal ganglia and left mesial temporal metabolism. These findings suggest that subjective mood state changes during PET may influence metabolism in brain regions implicated in emotion and memory function in people with age-related memory complaints. |
| Keywords: | Positron emission tomography (PET) Age-associated memory impairment (AAMI) Visual analogue scale Mood Emotion Asymmetry |
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