| 大鼠前额叶皮层多通道局部场电位和锋电位的频谱相干对工作记忆事件的编码 |
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| 引用本文： | 刘迢迢,白文文,孙洋,田心. 大鼠前额叶皮层多通道局部场电位和锋电位的频谱相干对工作记忆事件的编码[J]. 国际生物医学工程杂志, 2010, 34(6): 5-10,后插5. DOI: 10.3760/cma.j.issn.1673-4181.2011.01.002 |
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| 作者姓名： | 刘迢迢 白文文 孙洋 田心 |
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| 作者单位： | 天津医科大学基础医学研究中心,300070;天津神经病学研究所,300052; |
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| 摘 要： | Objective To investigate how neural signals coherently encode working memory based on spectrum coherence of two types of multi-channel neural signals from rat prefrontal cortex. Methods Cerebus 128 Data Acquisition System was introduced to record two types of multi-channel neural singals: continuous time series (local field potentials, LFPs) and discrete time series (spikes), which were acquired on prefrontal cortex of rats during working memory task of Y maze. Short-Time Fouries Transform (STFT) was applied to calculate the power spectrum density (PSD) of LFPs. Experiment data of multi-channel LFPs-Spikes were obtained from time interval of 5s before and after the event. Spectrum coherence of LFP and spike from each channel was calculated in the Multitaper window with 500ms length sliding from the beginning and 125ms overlapping. Results Spectrum coherence of 0.3-15 Hz multi-channel LFPs-Spikes at 2-4 s increased with statistical significance (P＜0.05). Conclusion Our results suggest that spectrum coherence of multi-channel LFPs-Spikes encodes and predicts the event effectively.
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| 关 键 词： | 局部场电位 锋电位 工作记忆 频谱相干 大鼠 |
Multi-channel local field potential-spike spectrum coherence in rat prefrontal cortex on the encoding of working memory |
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| Abstract: | |
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| Keywords: | Local field potentialsSpikesWorking memorySpectrum coherenceRat |
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