右美托咪啶的临床麻醉应用进展

背景 右美托咪啶为高效、高选择性的α2肾上腺素受体激动剂,具有镇静、镇痛和抗焦虑等作用.自1999年美国FDA批准将其用于ICU的镇静以来,其在临床麻醉中的应用也日益广泛.目的 综述右美托咪啶在临床麻醉中的应用进展,为该药在临床工作中的应用提供参考.内容 此文分别从作用机制及临床应用两方面,综述了右美托咪啶的镇静作用,镇痛作用,抑制术中应激反应,麻醉辅助作用及对术后恢复的影响等内容.趋向 右美托咪啶作为新型的麻醉辅助用药,其在临床麻醉中的应用具有广泛前景.

Advances of the clinical application of dexmedetomidine in anesthesia

Background Dexmedetomidine, a potent and highly selective alpha2-adrenoreceptor agonist, acts with sedative,analgesic and anxiolytic properties. Since it was approved for sedation in intensive care unit (ICU) by the Food and Drug Administration of US in 1999, it has been increasingly used in clinical anesthesia. Purpose The aim of this review was to outline the advances of its use in clinical anesthesia and provide practical guidance for clinical anesthetists. Content From the aspects of mechanism of action and clinical application, we reviewed different properties of sedation, analgesia, inhibition of intraoperative stress response, aid in anesthesia and influence on postoperative recovery of dexmedetomidine. Trend As a new anesthetic adjuvant, the clinical application of dexmedetomidine in anesthesia is quite promising.