百忧解对2型糖尿病心理障碍患者治疗的临床研究

目的　了解百忧解对 2型糖尿病患者心理障碍的治疗效果。方法　选择 2型糖尿病合并抑郁及焦虑症状患者 40例随机分为百忧解组 (2 2例 )及对照组 (18例 ) ,百忧解组除常规糖尿病药物治疗外辅以百忧解治疗 12周 ,对照组仅进行常规糖尿病药物治疗 ,测治疗前后两组患者HAMD及HAMA评分、空腹血糖 (FPG)、糖化血红蛋白 (HbA1c)、肝肾功能及血尿便常规。结果　治疗后百忧解组及对照组抑郁及焦虑评分均减低 ,百忧解组改善更明显 (P <0 .0 1) ,同时两组FPG及HbA1c水平均有所下降 ,百忧解组下降幅度明显大于对照组 (P <0 .0 1)。结论　百忧解可以明显改善 2型糖尿病患者的抑郁及焦虑症状 ,有助于患者血糖的控制。

Clinical study on the effects of fluoxetine on the mental disorder of type 2 diabetes mellitus patients

Objective To explore the effects of fluoxetine on the mental disorder of type 2 diabetes mellitus patients. Methods 40 type 2 diabetes mellitus patients with depression and anxiety were chosen, they were randomly divided into the fluoxetine group and control group. One was intervened with routine treatment together with fluoxetine intervention, the other as control with routine treatment only. All patients were assessed by HAMD and HAMA. FPG, HbA1c, liver and renal function, blood and urine routine were measured before and after intervention. Results After 12 weeks , compared with control group fluoxetine group showed a significant fall in HAMD and HAMA score( P <0.01), the level of FPG and HbA1c decreased significantly( P <0.01). Conclusion Fluoxetine could significantly ameliorate the disturbances and also carbohydrate metabolism in type 2 diabetes mellitus patients.