血清同型半胱氨酸水平与缺血性脑血管病患者颈动脉粥样硬化的相关性研究

目的:探讨血清同型半胱氨酸(Hcy)水平与缺血性脑血管病(ICVD)患者颈动脉粥样硬化(CAS)的相关性。方法:回顾分析2013年4月到2014年4月于本院心内科确诊的ICVD患者80例,根据CAS程度将其分成3组:颈动脉正常组(A组),颈动脉内膜-中层增厚组(B组)和CAS组(C组),比较3组患者Hcy水平,并行Spearman分析评价Hcy与CAS的相关性。结果:B组和C组Hcy浓度均明显高于A组(P<0.05),C组Hcy浓度显著高于B组,差异有统计学意义(P<0.05),Hcy水平和颈动脉内膜中层厚度IMT呈正向相关性(r=0.751,P<0.05)。结论:ICVD患者血清Hcy水平与CAS密切相关,检测Hcy对评估ICVD患者CAS病变程度具有重要的临床价值。

Correlation between of serum homocysteine level and carotid atherosclero-sis in patients with ischemic cerebrovascular disease

Objective:To access the correlation between the level of serum homocysteine (Hcy)and carotid atherosclerosis (CAS)in patients with ischemic cerebrovascular disease (ICVD).Methods:A total of 80 cases with ICVD diagnosed in the Depart-ment of Cardiology of our hospital from April 2013 to April 2014 were enrolled.According to the severity of CAS,they were divided into three groups:carotid artery normal group (group A),carotid intima-media thickening (group B)and carotid atherosclerosis group (group C).The Hcy levels of the three groups were compared.Spearman’s rank correlation was also conducted to assess the correla-tion between the Hcy level and CAS.Results:The Hcy levels in group B and C were significantly higher than that of group A (P <0.05).The Hcy level in group C were also higher than that of group B (P<0.05).Positive correlation between serum Hcy level and carotid intima-media thickness was found (r=0.751,P<0.05).Conclusion:The serum Hcy level was closely associated with CAS in ICVD patients.The detection of Hcy has important clinical value in evaluating the severity of CAS in ICVD patients.