幽门螺杆菌感染慢性胃炎患者红细胞免疫功能变化的研究

目的　探讨红细胞免疫在幽门螺杆菌感染慢性胃炎发病机制中的作用。方法　对 91例 Hp(+)慢性胃炎患者 [Hp(+)组 ],给予抗 Hp三联 +胃动力药治疗 2周 ;2 2例 Hp(- )慢性胃炎患者 ,给予胃粘膜保护剂 +胃动力药治疗 2周。治疗前及治疗结束后 2个月分别进行胃镜及 Hp检测 ,并测定两组红细胞免疫功能及胃粘膜屏障功能。结果　治疗前 Hp(+)组与 Hp(- )组红细胞免疫功能比较 ,前者 RBC- C3b RR偏低 ,而 RBC- ICR偏高 ,胃粘膜屏障功能较差 (P<0 .0 5 ) ;治疗后两组间无显著性差异 (P>0 .0 5 )。结论　慢性胃炎患者红细胞免疫功能降低 ,其与 Hp感染存在相关性。

Abnormal erythrocytic immunofuction in patients of chronic gastritis with helicobacter pylori

Objective To explore the effect of immunological function of erythrocytes on chronic gastritis infected with Helicobacter pylori (Hp). Methods 91 cases of Hp (+) chronic gastritis were treated with colloidal bismuth subcitrate,amoxicillin,metronidazole for two weeks,and 22 cases with Hp (-) served as control,treated with prepulsid,smecta for two weeks.Immunofunction and gastric mucosal barrier status were examined before and 2 months after treatment.Results Rate of red blood cell C3b receptor rosette (RBC-C3bRR) in Hp (+) group was reduced significantly,while rate of red blood cell immune complex rosette (RBC-ICR) was elevated markedly compared with that of Hp (-) group (P<0.05).Both rates were closed to normal level after treatment.Weaker status of gastric mucosal barrier in Hp (+) group was observed [P<0.05 vs Hp(-) group].Treatment with anti-Hp improved gastric erythrocytic immunological function.Conclusion Abnormal function of red blood cells in chronic gastritis correlates with Hp infection.